Info
| ID | 1558 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | RAED-C |
| SMILES | Cc1ccc(C(C)C)cc1.NCCN.[Cl-] |
TUCAN
C12ClN2Ru/(1-8)(2-8)(3-9)(4-6)(4-10)(5-7)(5-10)(6-9)(7-9)(8-10)(11-12)(11-13)(12-14)
Measurements (24)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SW480 | 3.5 | — | 10.1039/b822725j | 2009 |
| A2780cisR | 4 | — | 10.1016/j.jorganchem.2017.05.0... | 2017 |
| CH-1 | 4.4 | — | 10.1039/b822725j | 2009 |
| A2780 | 4.5 | — | 10.1038/ncomms4462 | 2014 |
| A172 | 5 | — | 10.1002/ejic.200601149 | 2007 |
| A2780 | 5 | — | 10.1016/j.jorganchem.2017.05.0... | 2017 |
| A2780cisR | 6 | — | 10.1038/sj.bjc.6600290 | 2002 |
| A2780cisR | 6.8 | — | 10.1038/ncomms4462 | 2014 |
| A549 | 7.1 | — | 10.1039/b822725j | 2009 |
| NB4 | 7.5 | — | 10.1039/c9sc03110c | 2019 |
| A2780 | 9 | — | 10.1021/jm010051m | 2001 |
| A2780 | 10 | — | 10.1038/sj.bjc.6600290 | 2002 |
| NCI-H460 | 10 | — | 10.1002/chem.201200938 | 2012 |
| MCF-7 | 12 | — | 10.1021/ic4002626 | 2013 |
| MCF-7 | 13 | — | 10.1016/j.ejmech.2014.02.062 | 2014 |
| HCT-116 | 20 | — | 10.1002/ejic.200601149 | 2007 |
| HeLa | 25 | — | 10.1039/c5dt01430a | 2015 |
| SNU-1 | 28 | — | 10.1016/j.jorganchem.2019.1210... | 2020 |
| MDA-MB-231 | 34 | — | 10.1016/j.jorganchem.2017.05.0... | 2017 |
| A549 | 37 | — | 10.1039/c4dt03983a | 2015 |
| MCF-7 | 44 | — | 10.1039/c4dt03983a | 2015 |
| GES-1 | 67 | — | 10.1016/j.jorganchem.2019.1210... | 2020 |
| AGS | 1.1e+02 | — | 10.1016/j.jorganchem.2019.1210... | 2020 |
| A2780/ADR | 1.5e+02 | — | 10.1038/sj.bjc.6600290 | 2002 |
🧬 Cell Death Types (1)
Apoptosis
high
«To verify the cell apoptosis resulting from the DNA binding of Ru-1, the expression of apoptotic pathway proteins, including caspase-3, cleaved caspase-3, PARP-1 and cleaved PARP-1, was measured... Th...»