home← all complexes Ir builderC^N familiesD-MPNN

Complex #1558 — Ru(2) [RAED-C]

2D Structure

Structure
⬇ MOL V3000

Info

ID1558
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 2}
AbbreviationRAED-C
SMILESCc1ccc(C(C)C)cc1.NCCN.[Cl-]

TUCAN

C12ClN2Ru/(1-8)(2-8)(3-9)(4-6)(4-10)(5-7)(5-10)(6-9)(7-9)(8-10)(11-12)(11-13)(12-14)

Measurements (24)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
SW4803.5— 10.1039/b822725j 2009
A2780cisR4— 10.1016/j.jorganchem.2017.05.0... 2017
CH-14.4— 10.1039/b822725j 2009
A27804.5— 10.1038/ncomms4462 2014
A1725— 10.1002/ejic.200601149 2007
A27805— 10.1016/j.jorganchem.2017.05.0... 2017
A2780cisR6— 10.1038/sj.bjc.6600290 2002
A2780cisR6.8— 10.1038/ncomms4462 2014
A5497.1— 10.1039/b822725j 2009
NB47.5— 10.1039/c9sc03110c 2019
A27809— 10.1021/jm010051m 2001
A278010— 10.1038/sj.bjc.6600290 2002
NCI-H46010— 10.1002/chem.201200938 2012
MCF-712— 10.1021/ic4002626 2013
MCF-713— 10.1016/j.ejmech.2014.02.062 2014
HCT-11620— 10.1002/ejic.200601149 2007
HeLa25— 10.1039/c5dt01430a 2015
SNU-128— 10.1016/j.jorganchem.2019.1210... 2020
MDA-MB-23134— 10.1016/j.jorganchem.2017.05.0... 2017
A54937— 10.1039/c4dt03983a 2015
MCF-744— 10.1039/c4dt03983a 2015
GES-167— 10.1016/j.jorganchem.2019.1210... 2020
AGS1.1e+02— 10.1016/j.jorganchem.2019.1210... 2020
A2780/ADR1.5e+02— 10.1038/sj.bjc.6600290 2002

🧬 Cell Death Types (1)

Apoptosis high
«To verify the cell apoptosis resulting from the DNA binding of Ru-1, the expression of apoptotic pathway proteins, including caspase-3, cleaved caspase-3, PARP-1 and cleaved PARP-1, was measured... Th...»

Source-assisted 2D generator

Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.

experimental validation surface
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