Info
| ID | 155 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ru-2 |
| SMILES | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1.N[C@H]1CCCC[C@@H]1N.[Cl-] |
TUCAN
C21H24ClN5Ru/(1-34)(2-33)(3-43)(4-30)(5-37)(6-44)(7-33)(8-32)(9-31)(10-29)(11-36)(12-36)(13-34)(14-35)(15-35)(16-38)(17-25)(18-27)(19-28)(20-26)(21-46)(22-46)(23-47)(24-47)(25-28)(25-38)(26-28)(26-40)(27-39)(27-45)(29-30)(29-37)(30-31)(31-42)(32-41)(32-45)(33-34)(33-43)(34-35)(35-36)(36-44)(37-48)(38-50)(39-40)(39-49)(40-50)(41-42)(41-49)(42-48)(43-44)(43-46)(44-47)(45-51)(49-52)(50-52)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 20 | — | 10.3390/molecules25204699 | 2020 |
| HCT-116 | 50 | — | 10.3390/molecules25204699 | 2020 |
| SW480 | 86 | — | 10.3390/molecules25204699 | 2020 |
| CT-26 | 1.5e+02 | — | 10.3390/molecules25204699 | 2020 |
| SW480 | 1.6e+02 | — | 10.3390/molecules25204699 | 2020 |
| CT-26 | 1.7e+02 | — | 10.3390/molecules25204699 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both ruthenium(II) terpyridine complexes exerted a moderate apoptotic effect in colon carcinoma cells, but induced significant necrotic death.»