Info
| ID | 154 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ru-1 |
| SMILES | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1.NCCN.[Cl-] |
TUCAN
C17H18ClN5Ru/(1-26)(2-27)(3-22)(4-23)(5-28)(6-29)(7-20)(8-21)(9-25)(10-29)(11-24)(12-30)(13-19)(14-30)(15-36)(16-36)(17-37)(18-37)(19-34)(19-35)(20-23)(20-27)(21-23)(21-32)(22-31)(22-35)(24-26)(24-33)(25-26)(25-28)(27-39)(28-38)(29-30)(29-36)(30-37)(31-32)(31-40)(32-39)(33-34)(33-38)(34-40)(35-41)(39-42)(40-42)
Measurements (12)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 19 | — | 10.3390/molecules25204699 | 2020 |
| HCT-116 | 32 | — | 10.3390/molecules25204699 | 2020 |
| CT-26 | 33 | — | 10.1039/c5dt04132e | 2016 |
| CT-26 | 43 | — | 10.3390/molecules25204699 | 2020 |
| SW480 | 45 | — | 10.3390/molecules25204699 | 2020 |
| SW480 | 50 | — | 10.3390/molecules25204699 | 2020 |
| CT-26 | 51 | — | 10.3390/molecules25204699 | 2020 |
| A549 | 58 | — | 10.1039/c5dt04132e | 2016 |
| HCT-116 | 66 | — | 10.1039/c5dt04132e | 2016 |
| HeLa | 71 | — | 10.1016/j.jinorgbio.2016.10.00... | 2016 |
| MRC-5 | 87 | — | 10.1016/j.jinorgbio.2016.10.00... | 2016 |
| A549 | — | — | 10.1016/j.jinorgbio.2016.10.00... | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both ruthenium(II) terpyridine complexes exerted a moderate apoptotic effect in colon carcinoma cells, but induced significant necrotic death.»