Info
| ID | 149 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2, "P": 2} |
| Abbreviation | GA105 |
| SMILES | COC(=O)c1ccc(CN(CCN(Cc2ccc(C(=O)OC)cc2)P(c2ccccc2)c2ccccc2)P(c2ccccc2)c2ccccc2)cc1.Cc1ccc(C(C)C)cc1.[Cl-].[Cl-] |
TUCAN
C54H56N2O4P2Ru/(1-57)(2-59)(3-57)(4-63)(5-65)(6-74)(7-57)(8-58)(9-66)(10-68)(11-59)(12-58)(13-58)(14-64)(15-69)(16-60)(17-98)(18-70)(19-79)(20-99)(21-103)(22-67)(23-62)(24-76)(25-103)(26-99)(27-103)(28-71)(29-86)(30-61)(31-72)(32-87)(33-100)(34-75)(35-81)(36-59)(37-82)(38-101)(39-100)(40-101)(41-83)(42-84)(43-73)(44-90)(45-104)(46-104)(47-104)(48-80)(49-77)(50-78)(51-88)(52-89)(53-102)(54-102)(55-85)(56-91)(57-98)(58-98)(59-92)(60-62)(60-92)(61-86)(61-92)(62-93)(63-66)(63-107)(64-66)(64-68)(65-68)(65-107)(67-70)(67-76)(69-70)(69-108)(71-76)(71-108)(72-81)(72-109)(73-83)(73-109)(74-75)(74-97)(75-95)(77-84)(77-110)(78-85)(78-110)(79-80)(79-97)(80-95)(81-82)(82-83)(84-88)(85-88)(86-93)(87-89)(87-94)(89-96)(90-91)(90-94)(91-96)(93-98)(94-105)(95-101)(96-102)(97-106)(99-100)(99-111)(100-112)(101-111)(102-112)(103-115)(104-116)(105-113)(105-115)(106-114)(106-116)(107-117)(108-117)(109-118)(110-118)(111-117)(112-118)(115-119)(116-119)(117-119)(118-119)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A375 | 6.7 | — | 10.1016/j.bmcl.2020.127492 | 2020 |
| HEK293 | 14 | — | 10.1016/j.bmcl.2020.127492 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«flow cytometric analysis revealed that the mode of cell death of complex GA113 was apoptosis. Additionally, in cells treated with 10 µM of GA113 16.2% were in early apoptosis and 28.83% of cells were ...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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