Info
| ID | 148 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "P": 4} |
| Abbreviation | 2 |
| SMILES | O=C1C=C([O-])C(=O)c2ccccc21.c1ccc(P(CP(c2ccccc2)c2ccccc2)c2ccccc2)cc1.c1ccc(P(CP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C60H49O3P4Ru/(1-52)(2-57)(3-108)(4-51)(5-108)(6-50)(7-54)(8-58)(9-53)(10-59)(11-61)(12-64)(13-63)(14-60)(15-62)(16-65)(17-67)(18-70)(19-66)(20-68)(21-72)(22-109)(23-75)(24-69)(25-71)(26-73)(27-77)(28-76)(29-81)(30-83)(31-74)(32-78)(33-84)(34-79)(35-80)(36-109)(37-85)(38-82)(39-86)(40-90)(41-93)(42-87)(43-88)(44-94)(45-91)(46-92)(47-55)(48-56)(49-89)(50-51)(50-54)(51-52)(52-100)(53-58)(53-61)(54-57)(55-56)(55-89)(56-95)(57-100)(58-60)(59-63)(59-66)(60-101)(61-62)(62-101)(63-65)(64-68)(64-71)(65-102)(66-67)(67-102)(68-70)(69-73)(69-76)(70-103)(71-72)(72-103)(73-75)(74-81)(74-83)(75-104)(76-77)(77-104)(78-81)(78-105)(79-83)(79-105)(80-84)(80-106)(82-84)(82-90)(85-90)(85-106)(86-93)(86-107)(87-94)(87-107)(88-89)(88-96)(91-93)(91-94)(92-98)(92-99)(95-96)(95-97)(96-99)(97-98)(97-111)(98-110)(99-112)(100-113)(101-113)(102-114)(103-114)(104-115)(105-115)(106-116)(107-116)(108-113)(108-114)(109-115)(109-116)(113-117)(114-117)(115-117)(116-117)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.03 | — | 10.1016/j.jinorgbio.2020.11128... | 2020 |
| DU-145 | 0.06 | — | 10.1016/j.jinorgbio.2020.11128... | 2020 |
| MDA-MB-231 | 0.09 | — | 10.1016/j.jinorgbio.2020.11128... | 2020 |
| MCF-10A | 0.55 | — | 10.1016/j.jinorgbio.2020.11128... | 2020 |
| MCF-7 | 1.1 | — | 10.1016/j.jinorgbio.2020.11128... | 2020 |
| B16-F10 | 1.7 | — | 10.1016/j.jinorgbio.2021.11149... | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«The percentage of apoptotic cells increases considerably with an increase of the concentration of the complex (1) ... showing that the complex (1) induces tumor cell death via an apoptotic pathway.»