Info
| ID | 146 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru(II)-2 |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.Cc1ccc2ccc3ccc(C)nc3c2n1.Fc1ccc(/C=C/c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1 |
TUCAN
C49H37FN8Ru/(1-50)(2-38)(3-47)(4-49)(5-45)(6-44)(7-54)(8-38)(9-38)(10-60)(11-62)(12-39)(13-39)(14-55)(15-71)(16-51)(17-61)(18-39)(19-48)(20-40)(21-46)(22-57)(23-59)(24-42)(25-53)(26-40)(27-40)(28-72)(29-43)(30-41)(31-52)(32-58)(33-56)(34-41)(35-41)(36-63)(37-88)(38-73)(39-74)(40-75)(41-77)(42-44)(42-68)(43-58)(43-65)(44-86)(45-51)(45-64)(46-53)(46-86)(47-49)(47-73)(48-61)(48-74)(49-66)(50-54)(50-66)(51-71)(52-55)(52-75)(53-68)(54-67)(55-67)(56-63)(56-77)(57-59)(57-85)(58-72)(59-68)(60-62)(60-69)(61-69)(62-70)(63-70)(64-80)(64-81)(65-76)(65-79)(66-78)(67-82)(69-83)(70-84)(71-87)(72-93)(73-89)(74-91)(75-92)(76-80)(76-90)(77-94)(78-82)(78-89)(79-81)(79-93)(80-88)(81-87)(82-92)(83-84)(83-91)(84-94)(85-88)(85-90)(86-95)(89-96)(90-96)(91-96)(92-96)(93-96)(94-96)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 6.1 | — | 10.1016/j.saa.2019.117534 | 2020 |
| HeLa | 18 | — | 10.1016/j.saa.2019.117534 | 2020 |
| HepG2 | 19 | — | 10.1016/j.saa.2019.117534 | 2020 |
| SGC-7901 | 38 | — | 10.1016/j.saa.2019.117534 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«complexes Ru(II)-1 and Ru(II)-2 induced A549 cells apoptosis was mediated by increase of ROS levels and dysfunction of mitochondria»