Info
| ID | 145 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru(II)-1 |
| SMILES | C(=C/c1ccco1)\c1nc2c3cccnc3c3ncccc3c2[nH]1.Cc1ccc2ccc3ccc(C)nc3c2n1.Cc1ccc2ccc3ccc(C)nc3c2n1 |
TUCAN
C47H36N8ORu/(1-41)(2-43)(3-37)(4-45)(5-47)(6-37)(7-37)(8-38)(9-38)(10-53)(11-42)(12-48)(13-82)(14-58)(15-68)(16-50)(17-44)(18-51)(19-67)(20-46)(21-38)(22-39)(23-39)(24-49)(25-39)(26-57)(27-56)(28-40)(29-40)(30-52)(31-40)(32-55)(33-54)(34-59)(35-60)(36-85)(37-69)(38-71)(39-74)(40-79)(41-42)(41-61)(42-69)(43-47)(43-61)(44-51)(44-62)(45-46)(45-63)(46-71)(47-63)(48-49)(48-65)(49-74)(50-58)(50-64)(51-67)(52-54)(52-79)(53-55)(53-65)(54-66)(55-66)(56-57)(56-82)(57-83)(58-68)(59-60)(59-83)(60-81)(61-70)(62-73)(62-80)(63-72)(64-77)(64-78)(65-75)(66-76)(67-84)(68-89)(69-86)(70-72)(70-86)(71-87)(72-87)(73-77)(73-85)(74-88)(75-76)(75-88)(76-91)(77-90)(78-80)(78-89)(79-91)(80-84)(81-85)(81-90)(82-92)(83-92)(86-93)(87-93)(88-93)(89-93)(90-93)(91-93)(92-93)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 4.1 | — | 10.1016/j.saa.2019.117534 | 2020 |
| HeLa | 24 | — | 10.1016/j.saa.2019.117534 | 2020 |
| SGC-7901 | 27 | — | 10.1016/j.saa.2019.117534 | 2020 |
| HepG2 | — | — | 10.1016/j.saa.2019.117534 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«complexes Ru(II)-1 and Ru(II)-2 induced A549 cells apoptosis was mediated by increase of ROS levels and dysfunction of mitochondria»