Info
| ID | 1439 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1} |
| Abbreviation | 4 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[Cl-].c1ccncc1 |
TUCAN
C15Cl2NRu/(1-13)(2-12)(3-13)(4-10)(4-14)(5-6)(5-12)(6-11)(7-8)(7-12)(8-11)(9-10)(9-15)(11-13)(14-16)(15-16)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 3.4 | — | 10.1002/chem.201403974 | 2015 |
| SW620 | 4.1 | — | 10.1002/chem.201403974 | 2015 |
| HCT-116 | 4.6e+02 | — | 10.1021/acs.organomet.7b00842 | 2018 |
| HEp-2 | — | — | 10.1016/j.jorganchem.2018.11.0... | 2018 |
| COLO-205 | — | — | 10.1002/chem.201403974 | 2015 |
| HepG2 | — | — | 10.1021/acs.organomet.7b00842 | 2018 |
| A549 | — | — | 10.1021/acs.organomet.7b00842 | 2018 |
| HT-29 | — | — | 10.1021/acs.inorgchem.8b02542 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometry studies showed that complexes 2−4 can block the cell cycle in G2/M phase and produce death of tumor cells through an apoptotic pathway. Moreover, complexes 2−4 can activate the expressi...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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