Info
| ID | 1429 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"S": 1, "O": 1, "N": 3} |
| Abbreviation | Ru6 |
| SMILES | CS(C)=O.[Cl-].[Cl-].c1ccc(-c2cc(-c3ccc4ccc5cccc6ccc3c4c56)cc(-c3ccccn3)n2)nc1 |
TUCAN
C33H25N3ORuS/(1-33)(2-51)(3-36)(4-52)(5-26)(6-31)(7-41)(8-38)(9-40)(10-39)(11-29)(12-42)(13-34)(14-35)(15-27)(16-37)(17-32)(18-30)(19-28)(20-57)(21-57)(22-57)(23-58)(24-58)(25-58)(26-35)(26-43)(27-28)(27-43)(28-44)(29-42)(29-44)(30-37)(30-54)(31-35)(31-48)(32-37)(32-52)(33-49)(33-53)(34-36)(34-48)(36-46)(38-40)(38-41)(39-49)(39-56)(40-51)(41-55)(42-50)(43-47)(44-45)(45-46)(45-47)(46-50)(47-48)(49-50)(51-59)(52-60)(53-54)(53-61)(54-60)(55-56)(55-59)(56-61)(57-63)(58-63)(60-64)(61-64)(62-63)(63-64)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 3 | — | 10.1039/c7md00532f | 2018 |
| BEL-7404 | 5.1 | — | 10.1039/c7md00532f | 2018 |
| NCI-H460 | 5.9 | — | 10.1039/c7md00532f | 2018 |
| MGC-803 | 7.8 | — | 10.1039/c7md00532f | 2018 |
| HL-7702 | 28 | — | 10.1039/c7md00532f | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«After treatment with Ru1 (1.3 μM) and Ru6 (3.0 μM) for 24 h, the percentage of apoptotic cells (Q2 + Q3) increased from 2.22% to 38.60% and 29.00%...»