Info
| ID | 1428 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"S": 1, "O": 1, "N": 3} |
| Abbreviation | Ru5 |
| SMILES | CS(C)=O.[Cl-].[Cl-].c1ccc(-c2cc(-c3cccc4ccccc34)cc(-c3ccccn3)n2)nc1 |
TUCAN
C27H23N3ORuS/(1-34)(2-43)(3-30)(4-44)(5-25)(6-31)(7-35)(8-38)(9-37)(10-36)(11-32)(12-24)(13-26)(14-29)(15-28)(16-33)(17-27)(18-49)(19-49)(20-49)(21-50)(22-50)(23-50)(24-31)(24-39)(25-26)(25-39)(26-27)(27-40)(28-29)(28-44)(29-33)(30-32)(30-41)(31-32)(33-45)(34-42)(34-46)(35-36)(35-37)(36-47)(37-43)(38-42)(38-48)(39-41)(40-41)(40-42)(43-51)(44-52)(45-46)(45-52)(46-53)(47-48)(47-51)(48-53)(49-55)(50-55)(52-56)(53-56)(54-55)(55-56)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 4.9 | — | 10.1039/c7md00532f | 2018 |
| NCI-H460 | 6.7 | — | 10.1039/c7md00532f | 2018 |
| BEL-7404 | 8.5 | — | 10.1039/c7md00532f | 2018 |
| MGC-803 | 10 | — | 10.1039/c7md00532f | 2018 |
| HL-7702 | 35 | — | 10.1039/c7md00532f | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«After treatment with Ru1 (1.3 μM) and Ru6 (3.0 μM) for 24 h, the percentage of apoptotic cells (Q2 + Q3) increased from 2.22% to 38.60% and 29.00%...»