Info
| ID | 1427 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 3, "S": 1, "O": 1} |
| Abbreviation | Ru4 |
| SMILES | COc1cccc(-c2cc(-c3ccccn3)nc(-c3ccccn3)c2)c1.CS(C)=O.[Cl-].[Cl-] |
TUCAN
C24H23N3O2RuS/(1-46)(2-32)(3-44)(4-38)(5-28)(6-31)(7-24)(8-39)(9-29)(10-44)(11-34)(12-46)(13-46)(14-25)(15-33)(16-26)(17-44)(18-35)(19-47)(20-27)(21-30)(22-47)(23-47)(24-37)(24-45)(25-36)(25-43)(26-29)(26-45)(27-29)(27-37)(28-30)(28-38)(30-32)(31-36)(31-41)(32-40)(33-34)(33-39)(34-35)(35-42)(36-37)(38-50)(39-48)(40-41)(40-50)(41-49)(42-43)(42-48)(43-49)(44-52)(45-52)(46-53)(47-53)(49-54)(50-54)(51-53)(52-54)(53-54)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 6 | — | 10.1039/c7md00532f | 2018 |
| NCI-H460 | 8.9 | — | 10.1039/c7md00532f | 2018 |
| BEL-7404 | 10 | — | 10.1039/c7md00532f | 2018 |
| MGC-803 | 11 | — | 10.1039/c7md00532f | 2018 |
| HL-7702 | 40 | — | 10.1039/c7md00532f | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«After treatment with Ru1 (1.3 μM) and Ru6 (3.0 μM) for 24 h, the percentage of apoptotic cells (Q2 + Q3) increased from 2.22% to 38.60% and 29.00%...»