Info
| ID | 1425 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 3, "S": 1, "O": 1} |
| Abbreviation | Ru2 |
| SMILES | COc1ccc(-c2cc(-c3ccccn3)nc(-c3ccccn3)c2)cc1.CS(C)=O.[Cl-].[Cl-] |
TUCAN
C24H23N3O2RuS/(1-46)(2-31)(3-44)(4-38)(5-35)(6-32)(7-26)(8-25)(9-24)(10-44)(11-33)(12-46)(13-46)(14-30)(15-39)(16-28)(17-44)(18-34)(19-47)(20-29)(21-27)(22-47)(23-47)(24-26)(24-36)(25-37)(25-40)(26-45)(27-31)(27-32)(28-30)(28-45)(29-37)(29-42)(30-36)(31-38)(32-41)(33-34)(33-39)(34-35)(35-43)(36-37)(38-50)(39-48)(40-43)(40-49)(41-42)(41-50)(42-49)(43-48)(44-52)(45-52)(46-53)(47-53)(49-54)(50-54)(51-53)(52-54)(53-54)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 10 | — | 10.1039/c7md00532f | 2018 |
| MGC-803 | 15 | — | 10.1039/c7md00532f | 2018 |
| NCI-H460 | 16 | — | 10.1039/c7md00532f | 2018 |
| BEL-7404 | 19 | — | 10.1039/c7md00532f | 2018 |
| HL-7702 | 21 | — | 10.1039/c7md00532f | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«After treatment with Ru1 (1.3 μM) and Ru6 (3.0 μM) for 24 h, the percentage of apoptotic cells (Q2 + Q3) increased from 2.22% to 38.60% and 29.00%...»