Info
| ID | 1424 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4, "S": 1, "O": 1} |
| Abbreviation | Ru1 |
| SMILES | CCN(CC)c1ccc(-c2cc(-c3ccccn3)nc(-c3ccccn3)c2)cc1.CS(C)=O.[Cl-].[Cl-] |
TUCAN
C27H30N4ORuS/(1-31)(2-48)(3-56)(4-33)(5-31)(6-38)(7-43)(8-49)(9-37)(10-47)(11-36)(12-39)(13-40)(14-49)(15-31)(16-34)(17-56)(18-56)(19-44)(20-32)(21-50)(22-32)(23-35)(24-57)(25-41)(26-50)(27-42)(28-57)(29-57)(30-32)(31-49)(32-50)(33-34)(33-48)(34-35)(35-52)(36-37)(36-41)(37-47)(38-39)(38-46)(39-51)(40-45)(40-53)(41-55)(42-43)(42-51)(43-46)(44-45)(44-54)(45-46)(47-60)(48-58)(49-59)(50-59)(51-59)(52-54)(52-58)(53-55)(53-61)(54-61)(55-60)(56-63)(57-63)(60-64)(61-64)(62-63)(63-64)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 1.3 | — | 10.1039/c7md00532f | 2018 |
| BEL-7404 | 2.9 | — | 10.1039/c7md00532f | 2018 |
| NCI-H460 | 3.6 | — | 10.1039/c7md00532f | 2018 |
| MGC-803 | 6 | — | 10.1039/c7md00532f | 2018 |
| HL-7702 | 31 | — | 10.1039/c7md00532f | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«After treatment with Ru1 (1.3 μM) and Ru6 (3.0 μM) for 24 h, the percentage of apoptotic cells (Q2 + Q3) increased from 2.22% to 38.60% and 29.00%...»