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Complex #140 — Ru(2) [[Ru(bpy)3]2+]

2D Structure

Structure
⬇ MOL V3000

Info

ID140
MetalRu
Oxidation state2
Charge2
Donor atoms{"N": 6}
Abbreviation[Ru(bpy)3]2+
SMILESc1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1

TUCAN

C30H24N6Ru/(1-29)(2-25)(3-26)(4-30)(5-43)(6-44)(7-28)(8-27)(9-32)(10-45)(11-46)(12-31)(13-36)(14-35)(15-33)(16-34)(17-39)(18-40)(19-37)(20-38)(21-42)(22-41)(23-47)(24-48)(25-26)(25-29)(26-43)(27-28)(27-30)(28-44)(29-49)(30-50)(31-32)(31-45)(32-33)(33-51)(34-36)(34-52)(35-36)(35-46)(37-40)(37-53)(38-42)(38-54)(39-40)(39-47)(41-42)(41-48)(43-55)(44-56)(45-57)(46-58)(47-59)(48-60)(49-50)(49-55)(50-56)(51-53)(51-57)(52-54)(52-58)(53-59)(54-60)(55-61)(56-61)(57-61)(58-61)(59-61)(60-61)

Measurements (48)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MDA-MB-231210.24 10.1021/jacs.4c11820 2024
HT-2932 10.1002/cmdc.200800039 2008
L641 10.1111/cbdd.14341 2023
HeLa537.5 10.1039/d0dt01684e 2020
A27801.6e+02 10.1002/cbic.200900013 2009
A2780cisR1.6e+02 10.1002/cbic.200900013 2009
A5491.8e+02 10.1039/c4mt00044g 2012
A3751.8e+02 10.1039/c4mt00044g 2012
HEK293T2.5e+02 10.1021/acs.inorgchem.4c00922 2024
MCF-73.4e+02 10.1039/c4mt00044g 2012
HepG23.9e+02 10.1039/c4mt00044g 2012
MCF-77.8e+02 10.1002/cmdc.200800039 2008
4T1 10.1038/s41467-021-25303-1 2021
HeLa1.6e+02 10.1039/C6CC10330H 2017
A5491.5e+02 10.1039/C6CC10330H 2017
LO21.7e+02 10.1039/C6CC10330H 2017
AGS 10.1016/j.jinorgbio.2016.07.01... 2016
KATO III 10.1016/j.jinorgbio.2016.07.01... 2016
HCT-116 10.1016/j.jinorgbio.2016.07.01... 2016
SW480 10.1016/j.jinorgbio.2016.07.01... 2016
A549 10.1016/j.jinorgbio.2017.07.00... 2017
A549 10.1016/j.jinorgbio.2017.07.00... 2017
CT-26 10.1016/j.jinorgbio.2017.07.00... 2017
CT-26 10.1016/j.jinorgbio.2017.07.00... 2017
A54931 10.1021/acs.molpharmaceut.4c01... 2025
4T1 10.1021/acs.molpharmaceut.4c01... 2025
HeLa 10.1002/anie.202504970 2025
A375 10.1002/anie.202504970 2025
MDA-MB-231 10.1002/anie.202504970 2025
SW620 10.1002/anie.202504970 2025
A549 10.1002/anie.202504970 2025
A549cisR 10.1002/anie.202504970 2025
HLF 10.1002/anie.202504970 2025
SGC-7901 10.1002/anie.202504970 2025
SGC-7901/DDP 10.1002/anie.202504970 2025
HeLa 10.1002/asia.202300047 2023
A549 10.1002/asia.202300047 2023
A549cisR 10.1002/asia.202300047 2023
PC-12 10.1039/c4mt00044g 2012
H358 10.1002/cmdc.202300347 2023
MCF-7 10.1002/cmdc.202300347 2023
HeLa 10.1002/ejic.201900569 2019
HeLa 10.1002/ejic.201900569 2019
RPE-1 10.1002/ejic.201900569 2019
RPE-1 10.1002/ejic.201900569 2019
T47D 10.1016/j.jinorgbio.2022.11193... 2022
H23 10.1016/j.jinorgbio.2022.11193... 2022
HEK2931.6 10.1021/jacs.4c11820 2024

🧬 Cell Death Types (2)

Apoptosis high
«causing cell cycle arrest in the G2/M phase and triggering apoptosis»
Immunogenic Cell Death high
«Furthermore, 8b also initiated an ICD cascade, enhancing recruitment and maturation of antigen-presenting cells, thus triggering a CD8+ T cell antitumor immune response.»