Info
| ID | 1322 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 2} |
| Abbreviation | 2mA |
| SMILES | COC(=O)C(C)NC(=O)c1cccc(P(c2ccccc2)c2ccccc2)c1.COC(=O)C(C)NC(=O)c1cccc(P(c2ccccc2)c2ccccc2)c1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C56H58N2O6P2Ru/(1-59)(2-59)(3-100)(4-59)(5-66)(6-60)(7-69)(8-78)(9-81)(10-62)(11-74)(12-68)(13-62)(14-65)(15-79)(16-70)(17-89)(18-60)(19-103)(20-72)(21-76)(22-67)(23-77)(24-82)(25-73)(26-61)(27-61)(28-64)(29-61)(30-80)(31-101)(32-75)(33-62)(34-84)(35-88)(36-60)(37-63)(38-90)(39-91)(40-63)(41-92)(42-71)(43-87)(44-94)(45-83)(46-86)(47-103)(48-103)(49-85)(50-95)(51-104)(52-104)(53-63)(54-93)(55-102)(56-104)(57-115)(58-116)(59-100)(60-101)(61-100)(62-96)(63-102)(64-78)(64-97)(65-79)(65-111)(66-69)(66-109)(67-69)(67-74)(68-74)(68-109)(70-76)(70-110)(71-87)(71-112)(72-77)(72-110)(73-76)(73-77)(75-80)(75-83)(78-96)(79-88)(80-82)(81-84)(81-96)(82-113)(83-90)(84-97)(85-86)(85-93)(86-91)(87-94)(88-98)(89-98)(89-111)(90-113)(91-114)(92-93)(92-114)(94-99)(95-99)(95-112)(97-100)(98-105)(99-106)(101-107)(101-115)(102-108)(102-116)(103-121)(104-122)(105-115)(105-118)(106-116)(106-119)(107-117)(107-121)(108-120)(108-122)(109-123)(110-123)(111-123)(112-124)(113-124)(114-124)(121-125)(122-125)(123-125)(124-125)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 5 | — | 10.1016/j.bioorg.2019.03.048 | 2019 |
🧬 Cell Death Types (1)
Autophagy
high
«Further investigation determined autophagy as the mode of cell death.»