Info
| ID | 1318 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | [Ru(dip)2(bpy)]2+ |
| SMILES | c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C58H40N6Ru/(1-44)(2-42)(3-87)(4-43)(5-45)(6-46)(7-67)(8-68)(9-52)(10-50)(11-41)(12-51)(13-58)(14-90)(15-54)(16-47)(17-62)(18-48)(19-49)(20-57)(21-53)(22-91)(23-88)(24-89)(25-60)(26-66)(27-63)(28-92)(29-70)(30-59)(31-64)(32-61)(33-65)(34-56)(35-73)(36-69)(37-72)(38-55)(39-71)(40-74)(41-75)(41-87)(42-43)(42-77)(43-79)(44-45)(44-78)(45-58)(46-50)(46-78)(47-51)(47-80)(48-57)(48-80)(49-60)(49-81)(50-58)(51-59)(52-56)(52-84)(53-63)(53-81)(54-82)(54-90)(55-67)(55-96)(56-85)(57-59)(60-61)(61-63)(62-76)(62-91)(64-66)(64-69)(65-83)(65-92)(66-86)(67-68)(68-88)(69-73)(70-73)(70-86)(71-74)(71-97)(72-74)(72-89)(75-77)(75-78)(76-79)(76-80)(77-93)(79-94)(81-82)(82-84)(83-85)(83-86)(84-95)(85-98)(87-99)(88-102)(89-103)(90-100)(91-101)(92-104)(93-94)(93-99)(94-101)(95-98)(95-100)(96-97)(96-102)(97-103)(98-104)(99-105)(100-105)(101-105)(102-105)(103-105)(104-105)
Measurements (17)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.8 | — | 10.1021/acs.jmedchem.2c00580 | 2022 |
| PANC-1 | 1.1 | — | 10.1016/j.ejps.2017.01.020 | 2017 |
| HaCaT | 1.3 | — | 10.1016/j.ejps.2017.01.020 | 2017 |
| MCF-7 | 2.1 | — | 10.1002/cmdc.202300347 | 2023 |
| PANC-1 | 2.9 | — | 10.1016/j.ejps.2017.01.020 | 2017 |
| H358 | 3 | — | 10.1002/cmdc.202300347 | 2023 |
| CT-26 | 3.4 | — | 10.1016/j.jinorgbio.2017.07.00... | 2017 |
| MCF-7 | 3.9 | — | 10.1021/acs.jmedchem.2c00580 | 2022 |
| A549 | 4 | — | 10.1016/j.jinorgbio.2017.07.00... | 2017 |
| MAgEC 10.5 | 4.2 | — | 10.1007/s00775-014-1187-5 | 2014 |
| HaCaT | 4.3 | — | 10.1016/j.ejps.2017.01.020 | 2017 |
| MLuMEC | 4.7 | — | 10.1007/s00775-014-1187-5 | 2014 |
| A2058 | 4.9 | — | 10.1021/acs.jmedchem.2c00580 | 2022 |
| 4T1 | 6.8 | — | 10.1007/s00775-014-1187-5 | 2014 |
| A375 | 9.7 | — | 10.1021/acs.jmedchem.2c00580 | 2022 |
| A549 | 14 | — | 10.1007/s00775-014-1187-5 | 2014 |
| HaCaT | 22 | — | 10.1021/acs.jmedchem.2c00580 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«4T1 cells after incubation with ruthenium compounds show marked morphological sign of apoptosis, such as decreasing amount of detached cells, cells rounding and shrinkage... The results suggest that c...»