Info
| ID | 1311 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 2(2+) |
| SMILES | c1ccc2nc3c4cccnc4c4ncccc4c3nc2c1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C42H26N8Ru/(1-38)(2-55)(3-53)(4-28)(5-54)(6-29)(7-35)(8-40)(9-27)(10-56)(11-41)(12-30)(13-34)(14-37)(15-36)(16-44)(17-45)(18-46)(19-31)(20-57)(21-39)(22-58)(23-43)(24-42)(25-33)(26-32)(27-31)(27-47)(28-35)(28-47)(29-40)(29-48)(30-42)(30-48)(31-49)(32-33)(32-34)(33-46)(34-62)(35-53)(36-41)(36-49)(37-39)(37-50)(38-45)(38-55)(39-58)(40-54)(41-56)(42-51)(43-44)(43-57)(44-51)(45-52)(46-68)(47-59)(48-60)(49-65)(50-63)(50-64)(51-66)(52-61)(52-67)(53-71)(54-73)(55-72)(56-74)(57-75)(58-70)(59-65)(59-71)(60-66)(60-73)(61-63)(61-72)(62-68)(62-69)(63-70)(64-67)(64-69)(65-74)(66-75)(67-76)(68-76)(71-77)(72-77)(73-77)(74-77)(75-77)(76-77)
Measurements (14)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 18 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| NCI-H460 | 20 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| NCI-H460 | 30 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| H358 | 35 | — | 10.1002/cmdc.201700240 | 2017 |
| MCF-7 | 50 | — | 10.1002/cmdc.201700240 | 2017 |
| CCL228 | 50 | — | 10.1002/cmdc.201700240 | 2017 |
| MCF-10A | 50 | — | 10.1002/cmdc.201700240 | 2017 |
| HeLa | 1.5e+02 | — | 10.1021/jm1009296 | 2010 |
| HepG2 | 1.7e+02 | — | 10.1021/jm1009296 | 2010 |
| MCF-7 | 2.6e+02 | — | 10.1021/jm1009296 | 2010 |
| MCF-10A | 2.9e+02 | — | 10.1021/jm1009296 | 2010 |
| MDA-MB-231 | — | — | 10.1021/acs.nanolett.7b00132 | 2017 |
| MDA-MB-231 | — | — | 10.1021/acs.nanolett.7b00132 | 2017 |
| MDA-MB-231 | — | — | 10.1021/acs.nanolett.7b00132 | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«In addition, 75.9% of cells were apoptotic following exposure to Lipo-Ru for 12 h, while less than 5% displayed signs of apoptosis in Ru-treated cells and control cells ( Figure 5b and 5d ). To furthe...»