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Complex #1227 — Ru(2) [2]

2D Structure

Structure
⬇ MOL V3000

Info

ID1227
MetalRu
Oxidation state2
Charge2
Donor atoms{"N": 8}
Abbreviation2
SMILESCc1ccc2ccc3ccc(C)nc3c2n1.Cc1ccc2ccc3ccc(C)nc3c2n1.c1ccc2c(c1)cc(-c1nc3c4cccnc4c4ncccc4c3[nH]1)c1ccccc12

TUCAN

C55H40N8Ru/(1-54)(2-41)(3-41)(4-66)(5-62)(6-45)(7-55)(8-41)(9-51)(10-49)(11-42)(12-42)(13-48)(14-46)(15-63)(16-64)(17-42)(18-56)(19-50)(20-60)(21-43)(22-43)(23-58)(24-57)(25-82)(26-52)(27-61)(28-65)(29-53)(30-81)(31-47)(32-69)(33-67)(34-43)(35-59)(36-44)(37-44)(38-68)(39-44)(40-97)(41-84)(42-88)(43-92)(44-93)(45-61)(45-71)(46-53)(46-70)(47-65)(47-81)(48-49)(48-84)(49-73)(50-60)(50-74)(51-56)(51-73)(52-55)(52-72)(53-54)(54-63)(55-66)(56-74)(57-67)(57-75)(58-59)(58-75)(59-80)(60-88)(61-82)(62-78)(62-79)(63-79)(64-66)(64-77)(65-76)(67-92)(68-69)(68-93)(69-80)(70-72)(70-79)(71-86)(71-90)(72-77)(73-83)(74-85)(75-91)(76-87)(76-89)(77-78)(78-95)(80-94)(81-96)(82-101)(83-85)(83-98)(84-98)(85-100)(86-89)(86-99)(87-90)(87-96)(88-100)(89-97)(90-101)(91-94)(91-102)(92-102)(93-103)(94-103)(95-97)(95-99)(98-104)(99-104)(100-104)(101-104)(102-104)(103-104)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
SGC-790112 10.1039/c7ra05103d 2017
HepG2 10.1039/c7ra05103d 2017
HeLa 10.1039/c7ra05103d 2017
SiHa 10.1039/c7ra05103d 2017
NIH-3T3 10.1039/c7ra05103d 2017

🧬 Cell Death Types (2)

Apoptosis high
«The results demonstrate that the complexes induce apoptosis in SGC-7901 cells through a ROS-mediated mitochondrial dysfunction pathway»
Autophagy high
«which also indicates that complex 3 can induce autophagy»