Info
| ID | 1227 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 2 |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.Cc1ccc2ccc3ccc(C)nc3c2n1.c1ccc2c(c1)cc(-c1nc3c4cccnc4c4ncccc4c3[nH]1)c1ccccc12 |
TUCAN
C55H40N8Ru/(1-54)(2-41)(3-41)(4-66)(5-62)(6-45)(7-55)(8-41)(9-51)(10-49)(11-42)(12-42)(13-48)(14-46)(15-63)(16-64)(17-42)(18-56)(19-50)(20-60)(21-43)(22-43)(23-58)(24-57)(25-82)(26-52)(27-61)(28-65)(29-53)(30-81)(31-47)(32-69)(33-67)(34-43)(35-59)(36-44)(37-44)(38-68)(39-44)(40-97)(41-84)(42-88)(43-92)(44-93)(45-61)(45-71)(46-53)(46-70)(47-65)(47-81)(48-49)(48-84)(49-73)(50-60)(50-74)(51-56)(51-73)(52-55)(52-72)(53-54)(54-63)(55-66)(56-74)(57-67)(57-75)(58-59)(58-75)(59-80)(60-88)(61-82)(62-78)(62-79)(63-79)(64-66)(64-77)(65-76)(67-92)(68-69)(68-93)(69-80)(70-72)(70-79)(71-86)(71-90)(72-77)(73-83)(74-85)(75-91)(76-87)(76-89)(77-78)(78-95)(80-94)(81-96)(82-101)(83-85)(83-98)(84-98)(85-100)(86-89)(86-99)(87-90)(87-96)(88-100)(89-97)(90-101)(91-94)(91-102)(92-102)(93-103)(94-103)(95-97)(95-99)(98-104)(99-104)(100-104)(101-104)(102-104)(103-104)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | 12 | — | 10.1039/c7ra05103d | 2017 |
| HepG2 | — | — | 10.1039/c7ra05103d | 2017 |
| HeLa | — | — | 10.1039/c7ra05103d | 2017 |
| SiHa | — | — | 10.1039/c7ra05103d | 2017 |
| NIH-3T3 | — | — | 10.1039/c7ra05103d | 2017 |
🧬 Cell Death Types (2)
Apoptosis
high
«The results demonstrate that the complexes induce apoptosis in SGC-7901 cells through a ROS-mediated mitochondrial dysfunction pathway»
Autophagy
high
«which also indicates that complex 3 can induce autophagy»