Info
| ID | 1226 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 1 |
| SMILES | c1ccc2c(c1)cc(-c1nc3c4cccnc4c4ncccc4c3[nH]1)c1ccccc12.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C51H32N8Ru/(1-40)(2-43)(3-54)(4-55)(5-33)(6-69)(7-34)(8-37)(9-35)(10-70)(11-36)(12-72)(13-71)(14-44)(15-41)(16-73)(17-39)(18-45)(19-38)(20-42)(21-50)(22-48)(23-51)(24-46)(25-74)(26-53)(27-52)(28-56)(29-47)(30-57)(31-49)(32-85)(33-34)(33-69)(34-58)(35-37)(35-70)(36-49)(36-58)(37-63)(38-46)(38-63)(39-40)(39-41)(40-43)(41-59)(42-57)(42-60)(43-62)(44-59)(44-61)(45-50)(45-72)(46-64)(47-51)(47-74)(48-53)(48-65)(49-68)(50-64)(51-68)(52-56)(52-67)(53-57)(54-55)(54-73)(55-66)(56-71)(58-75)(59-62)(60-61)(60-65)(61-83)(62-65)(63-76)(64-77)(66-79)(66-82)(67-78)(67-81)(68-80)(69-86)(70-87)(71-84)(72-88)(73-89)(74-90)(75-80)(75-86)(76-77)(76-87)(77-88)(78-79)(78-84)(79-89)(80-90)(81-82)(81-85)(82-91)(83-85)(83-91)(86-92)(87-92)(88-92)(89-92)(90-92)(91-92)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | 14 | — | 10.1039/c7ra05103d | 2017 |
| SiHa | 61 | — | 10.1039/c7ra05103d | 2017 |
| HeLa | 72 | — | 10.1039/c7ra05103d | 2017 |
| HepG2 | — | — | 10.1039/c7ra05103d | 2017 |
| NIH-3T3 | — | — | 10.1039/c7ra05103d | 2017 |
🧬 Cell Death Types (2)
Apoptosis
high
«The results demonstrate that the complexes induce apoptosis in SGC-7901 cells through a ROS-mediated mitochondrial dysfunction pathway»
Autophagy
high
«which also indicates that complex 3 can induce autophagy»