Info
| ID | 1225 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 3, "S": 1, "O": 1, "P": 2} |
| Abbreviation | 4 |
| SMILES | C/C(=N\N=C(/[S-])Nc1ccccc1)c1[c-]c2ccccc2oc1=O.[C-]#[O+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C55H43N3O3P2RuS/(1-49)(2-51)(3-46)(4-47)(5-48)(6-53)(7-52)(8-50)(9-54)(10-59)(11-62)(12-56)(13-44)(14-57)(15-63)(16-66)(17-71)(18-55)(19-60)(20-61)(21-72)(22-64)(23-69)(24-75)(25-65)(26-44)(27-81)(28-44)(29-68)(30-76)(31-73)(32-74)(33-78)(34-77)(35-79)(36-80)(37-84)(38-83)(39-70)(40-67)(41-58)(42-82)(43-99)(44-87)(45-85)(45-86)(46-47)(46-48)(47-49)(48-51)(49-92)(50-52)(50-59)(51-92)(52-53)(53-93)(54-59)(54-93)(55-63)(55-94)(56-57)(56-88)(57-58)(58-67)(60-66)(60-94)(61-71)(61-95)(62-63)(62-66)(64-72)(64-95)(65-75)(65-96)(67-70)(68-76)(68-96)(69-71)(69-72)(70-88)(73-78)(73-97)(74-75)(74-76)(77-78)(77-79)(79-80)(80-97)(81-84)(81-90)(82-83)(82-84)(83-86)(85-87)(85-91)(86-90)(87-100)(88-99)(89-103)(90-104)(91-102)(91-104)(92-105)(93-105)(94-105)(95-106)(96-106)(97-106)(98-99)(98-101)(98-107)(100-101)(100-108)(101-108)(104-108)(105-108)(106-108)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 3.1 | — | 10.1039/c7nj02877f | 2018 |
| MCF-7 | 3.1 | — | 10.1039/c7nj02877f | 2018 |
| HaCaT | — | — | 10.1039/c7nj02877f | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»