Info
| ID | 1222 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 3, "S": 1, "O": 1, "P": 2} |
| Abbreviation | 1 |
| SMILES | C/C(=N\N=C(\N)[S-])c1[c-]c2ccccc2oc1=O.[C-]#[O+].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C49H39N3O3P2RuS/(1-42)(2-45)(3-43)(4-44)(5-46)(6-47)(7-50)(8-49)(9-52)(10-56)(11-51)(12-74)(13-54)(14-48)(15-57)(16-53)(17-55)(18-64)(19-58)(20-59)(21-60)(22-62)(23-61)(24-40)(25-40)(26-40)(27-65)(28-67)(29-63)(30-70)(31-68)(32-66)(33-69)(34-71)(35-75)(36-72)(37-73)(38-89)(39-89)(40-78)(41-76)(41-77)(42-44)(42-82)(43-44)(43-46)(45-46)(45-82)(47-49)(47-83)(48-52)(48-83)(49-50)(50-52)(51-74)(51-76)(53-54)(53-84)(54-56)(55-57)(55-84)(56-57)(58-59)(58-64)(59-85)(60-61)(60-85)(61-64)(62-65)(62-86)(63-67)(63-86)(65-70)(66-68)(66-87)(67-70)(68-75)(69-71)(69-87)(71-75)(72-73)(72-80)(73-74)(76-80)(77-78)(77-81)(78-90)(79-93)(80-94)(81-92)(81-94)(82-95)(83-95)(84-95)(85-96)(86-96)(87-96)(88-89)(88-91)(88-97)(90-91)(90-98)(91-98)(94-98)(95-98)(96-98)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 2.9 | — | 10.1039/c7nj02877f | 2018 |
| MCF-7 | 3 | — | 10.1039/c7nj02877f | 2018 |
| HaCaT | — | — | 10.1039/c7nj02877f | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»