Info
| ID | 120 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"P": 2} |
| Abbreviation | 5 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1 |
TUCAN
C54H46P2Ru/(1-57)(2-58)(3-59)(4-53)(5-54)(6-51)(7-60)(8-64)(9-74)(10-78)(11-62)(12-50)(13-63)(14-61)(15-66)(16-67)(17-69)(18-68)(19-70)(20-85)(21-72)(22-81)(23-65)(24-73)(25-82)(26-71)(27-75)(28-76)(29-80)(30-84)(31-79)(32-77)(33-47)(34-55)(35-47)(36-48)(37-56)(38-48)(39-48)(40-47)(41-49)(42-49)(43-49)(44-52)(45-94)(46-83)(47-86)(48-94)(49-94)(50-51)(50-90)(51-60)(52-55)(52-86)(53-57)(53-96)(54-58)(54-96)(55-88)(56-83)(56-88)(57-61)(58-61)(59-63)(59-70)(60-74)(62-65)(62-89)(63-97)(64-67)(64-70)(65-95)(66-69)(66-75)(67-97)(68-72)(68-75)(69-99)(71-73)(71-80)(72-99)(73-100)(74-89)(76-85)(76-93)(77-78)(77-85)(78-92)(79-84)(79-100)(80-84)(81-82)(81-92)(82-98)(83-86)(87-90)(87-91)(87-95)(88-94)(89-90)(91-93)(91-98)(92-93)(95-101)(96-101)(97-101)(98-102)(99-102)(100-102)(101-103)(102-103)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 1 | — | 10.1021/acs.inorgchem.7b01959 | 2017 |
| BEAS-2B | 1.3 | — | 10.1021/acs.inorgchem.7b01959 | 2017 |
| 16HBE | 1.3 | — | 10.1021/acs.inorgchem.7b01959 | 2017 |
| A549 | 1.4 | — | 10.1021/acs.inorgchem.7b01959 | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«The results suggested that cell death caused by the complexes was induced mainly through apoptosis.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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