Info
| ID | 1170 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ru1 |
| SMILES | [Cl-].c1ccc(-c2cccc(-c3ccccn3)n2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C25H19N5Ru/(1-32)(2-33)(3-38)(4-25)(5-29)(6-20)(7-26)(8-34)(9-36)(10-35)(11-37)(12-21)(13-23)(14-24)(15-22)(16-30)(17-31)(18-27)(19-28)(20-25)(20-39)(21-27)(21-40)(22-34)(22-42)(23-33)(23-38)(24-31)(24-36)(25-26)(26-35)(27-28)(28-37)(29-34)(29-44)(30-33)(30-43)(31-32)(32-41)(35-46)(36-47)(37-49)(38-45)(39-40)(39-46)(40-49)(41-44)(41-47)(42-43)(42-48)(43-45)(44-48)(46-50)(47-50)(48-50)(49-50)
Measurements (12)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 1e+02 | — | 10.1039/c6dt01270a | 2016 |
| A549 | 1.1e+02 | — | 10.1039/c6dt01270a | 2016 |
| BEL-7402 | 1.1e+02 | — | 10.1039/c6dt01270a | 2016 |
| HepG2 | 1.2e+02 | — | 10.1039/c6dt01270a | 2016 |
| A549cisR | 1.2e+02 | — | 10.1039/c6dt01270a | 2016 |
| LO2 | 1.3e+02 | — | 10.1039/c6dt01270a | 2016 |
| LO2 | — | — | 10.1039/c5dt02446c | 2015 |
| HepG2 | — | — | 10.1039/c5dt02446c | 2015 |
| BEL-7402 | — | — | 10.1039/c5dt02446c | 2015 |
| A549 | — | — | 10.1039/c5dt02446c | 2015 |
| A549cisR | — | — | 10.1039/c5dt02446c | 2015 |
| HeLa | — | — | 10.1039/c5dt02446c | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Antiproliferative assay revealed that Ru3 significantly inhibited cellular DNA replication which induced ultimately apoptosis of cancer cells.»