Info
| ID | 1098 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 6 |
| SMILES | CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.Fc1cc2ccccc2cc1Oc1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C64H63FN8ORu/(1-109)(2-81)(3-64)(4-110)(5-113)(6-64)(7-64)(8-65)(9-83)(10-92)(11-65)(12-65)(13-66)(14-66)(15-79)(16-111)(17-84)(18-66)(19-67)(20-67)(21-67)(22-68)(23-68)(24-68)(25-69)(26-69)(27-69)(28-70)(29-70)(30-70)(31-76)(32-71)(33-71)(34-71)(35-93)(36-90)(37-86)(38-72)(39-72)(40-80)(41-72)(42-95)(43-94)(44-88)(45-82)(46-91)(47-89)(48-73)(49-73)(50-114)(51-78)(52-87)(53-73)(54-74)(55-77)(56-74)(57-74)(58-75)(59-75)(60-85)(61-96)(62-112)(63-75)(64-105)(65-105)(66-105)(67-106)(68-106)(69-106)(70-107)(71-107)(72-107)(73-108)(74-108)(75-108)(76-92)(76-97)(77-93)(77-125)(78-98)(78-127)(79-100)(79-117)(80-101)(80-121)(81-100)(81-109)(82-103)(82-122)(83-101)(83-110)(84-103)(84-111)(85-104)(85-112)(86-95)(86-102)(87-102)(87-126)(88-89)(88-95)(89-98)(90-115)(90-125)(91-94)(91-114)(92-113)(93-123)(94-99)(96-104)(96-124)(97-118)(97-119)(98-102)(99-116)(99-120)(100-105)(101-106)(103-107)(104-108)(109-130)(110-131)(111-132)(112-135)(113-134)(114-128)(115-123)(115-129)(116-119)(116-128)(117-121)(117-130)(118-120)(118-133)(119-134)(120-129)(121-131)(122-124)(122-132)(123-133)(124-135)(125-136)(126-127)(126-136)(127-137)(130-138)(131-138)(132-138)(133-138)(134-138)(135-138)(136-138)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| LO2 | 2.1 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 3.2 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 3.2 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HOS | 4.9 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HepG2 | 5.6 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HeLa | 6.7 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| A549 | 8.2 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
🧬 Cell Death Types (2)
Apoptosis
high
«The results obtained show that the complexes induce apoptosis in BEL-7402 cells through a ROS-mediated mitochondrial dysfunction pathway.»
Autophagy
high
«the complexes can induce autophagy and restrain the cell invasion... the expression of LC3-II and Beclin-1 was increased.»
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Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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