Info
| ID | 1094 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 2 |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.Cc1ccc2ccc3ccc(C)nc3c2n1.c1ccc(Oc2ccc3nc4c5cccnc5c5ncccc5c4nc3c2)cc1 |
TUCAN
C52H38N8ORu/(1-47)(2-45)(3-54)(4-46)(5-51)(6-50)(7-49)(8-59)(9-48)(10-39)(11-39)(12-53)(13-62)(14-39)(15-40)(16-63)(17-73)(18-58)(19-60)(20-64)(21-40)(22-55)(23-40)(24-41)(25-61)(26-52)(27-56)(28-57)(29-41)(30-74)(31-44)(32-41)(33-42)(34-43)(35-65)(36-42)(37-42)(38-66)(39-77)(40-78)(41-80)(42-81)(43-44)(43-74)(44-69)(45-47)(45-77)(46-54)(46-78)(47-67)(48-53)(48-67)(49-50)(49-89)(50-58)(51-60)(51-68)(52-57)(52-58)(53-70)(54-70)(55-64)(55-80)(56-61)(56-83)(57-89)(59-84)(59-90)(60-73)(61-90)(62-63)(62-71)(63-72)(64-71)(65-66)(65-81)(66-72)(67-75)(68-76)(68-85)(69-79)(69-86)(70-82)(71-87)(72-88)(73-92)(74-95)(75-82)(75-93)(76-79)(76-91)(77-93)(78-94)(79-96)(80-97)(81-98)(82-94)(83-84)(83-96)(84-91)(85-86)(85-92)(86-95)(87-88)(87-97)(88-98)(89-99)(90-99)(93-100)(94-100)(95-100)(96-100)(97-100)(98-100)(99-100)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 2 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 2.2 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 2.2 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HeLa | 4.1 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HOS | 20 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| A549 | 25 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| LO2 | 30 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
🧬 Cell Death Types (2)
Apoptosis
high
«The results obtained show that the complexes induce apoptosis in BEL-7402 cells through a ROS-mediated mitochondrial dysfunction pathway.»
Autophagy
high
«the complexes can induce autophagy and restrain the cell invasion... the expression of LC3-II and Beclin-1 was increased.»