Info
| ID | 1093 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 1 |
| SMILES | Cc1ccnc(-c2cc(C)ccn2)c1.Cc1ccnc(-c2cc(C)ccn2)c1.c1ccc(Oc2ccc3nc4c5cccnc5c5ncccc5c4nc3c2)cc1 |
TUCAN
C48H38N8ORu/(1-39)(2-45)(3-39)(4-51)(5-49)(6-39)(7-40)(8-69)(9-71)(10-50)(11-73)(12-40)(13-70)(14-53)(15-60)(16-40)(17-72)(18-59)(19-46)(20-57)(21-44)(22-47)(23-55)(24-41)(25-41)(26-54)(27-58)(28-48)(29-41)(30-62)(31-43)(32-52)(33-42)(34-56)(35-42)(36-74)(37-61)(38-42)(39-63)(40-64)(41-66)(42-67)(43-48)(43-73)(44-46)(44-58)(45-49)(45-68)(46-47)(47-86)(48-65)(49-71)(50-63)(50-69)(51-63)(51-75)(52-64)(52-70)(53-64)(53-78)(54-76)(54-85)(55-58)(55-86)(56-66)(56-72)(57-59)(57-79)(59-85)(60-66)(60-83)(61-67)(61-74)(62-67)(62-84)(65-77)(65-82)(68-80)(68-81)(69-89)(70-90)(71-87)(72-93)(73-91)(74-94)(75-78)(75-89)(76-79)(76-88)(77-81)(77-92)(78-90)(79-92)(80-82)(80-87)(81-88)(82-91)(83-84)(83-93)(84-94)(85-95)(86-95)(89-96)(90-96)(91-96)(92-96)(93-96)(94-96)(95-96)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HOS | 11 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HeLa | 14 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| A549 | 17 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 20 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 20 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HepG2 | 23 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| LO2 | 37 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
🧬 Cell Death Types (2)
Apoptosis
high
«The results obtained show that the complexes induce apoptosis in BEL-7402 cells through a ROS-mediated mitochondrial dysfunction pathway.»
Autophagy
high
«the complexes can induce autophagy and restrain the cell invasion... the expression of LC3-II and Beclin-1 was increased.»