home← all complexes Ir builderC^N familiesD-MPNN

Complex #1093 — Ru(2) [1]

2D Structure

Structure
⬇ MOL V3000

Info

ID1093
MetalRu
Oxidation state2
Charge2
Donor atoms{"N": 8}
Abbreviation1
SMILESCc1ccnc(-c2cc(C)ccn2)c1.Cc1ccnc(-c2cc(C)ccn2)c1.c1ccc(Oc2ccc3nc4c5cccnc5c5ncccc5c4nc3c2)cc1

TUCAN

C48H38N8ORu/(1-39)(2-45)(3-39)(4-51)(5-49)(6-39)(7-40)(8-69)(9-71)(10-50)(11-73)(12-40)(13-70)(14-53)(15-60)(16-40)(17-72)(18-59)(19-46)(20-57)(21-44)(22-47)(23-55)(24-41)(25-41)(26-54)(27-58)(28-48)(29-41)(30-62)(31-43)(32-52)(33-42)(34-56)(35-42)(36-74)(37-61)(38-42)(39-63)(40-64)(41-66)(42-67)(43-48)(43-73)(44-46)(44-58)(45-49)(45-68)(46-47)(47-86)(48-65)(49-71)(50-63)(50-69)(51-63)(51-75)(52-64)(52-70)(53-64)(53-78)(54-76)(54-85)(55-58)(55-86)(56-66)(56-72)(57-59)(57-79)(59-85)(60-66)(60-83)(61-67)(61-74)(62-67)(62-84)(65-77)(65-82)(68-80)(68-81)(69-89)(70-90)(71-87)(72-93)(73-91)(74-94)(75-78)(75-89)(76-79)(76-88)(77-81)(77-92)(78-90)(79-92)(80-82)(80-87)(81-88)(82-91)(83-84)(83-93)(84-94)(85-95)(86-95)(89-96)(90-96)(91-96)(92-96)(93-96)(94-96)(95-96)

Measurements (7)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HOS11— 10.1016/j.jinorgbio.2017.04.02... 2017
HeLa14— 10.1016/j.jinorgbio.2017.04.02... 2017
A54917— 10.1016/j.jinorgbio.2017.04.02... 2017
BEL-740220— 10.1016/j.jinorgbio.2017.04.02... 2017
BEL-740220— 10.1016/j.jinorgbio.2017.04.02... 2017
HepG223— 10.1016/j.jinorgbio.2017.04.02... 2017
LO237— 10.1016/j.jinorgbio.2017.04.02... 2017

🧬 Cell Death Types (2)

Apoptosis high
«The results obtained show that the complexes induce apoptosis in BEL-7402 cells through a ROS-mediated mitochondrial dysfunction pathway.»
Autophagy high
«the complexes can induce autophagy and restrain the cell invasion... the expression of LC3-II and Beclin-1 was increased.»

Source-assisted 2D generator

Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.

experimental validation surface
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