Info
| ID | 1084 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 1 |
| SMILES | Cc1cc(C)n(C(c2nc3ccccc3[nH]2)n2nc(C)cc2C)n1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C28H34N6Ru/(1-37)(2-39)(3-39)(4-37)(5-35)(6-35)(7-35)(8-42)(9-49)(10-36)(11-36)(12-39)(13-38)(14-38)(15-48)(16-54)(17-47)(18-50)(19-37)(20-38)(21-41)(22-44)(23-41)(24-51)(25-43)(26-41)(27-46)(28-45)(29-36)(30-40)(31-40)(32-62)(33-40)(34-63)(35-54)(36-57)(37-58)(38-54)(39-53)(40-59)(41-60)(42-48)(42-52)(43-44)(43-46)(44-55)(45-46)(45-56)(47-57)(47-58)(48-53)(49-50)(49-52)(50-53)(51-59)(51-60)(52-54)(55-56)(55-67)(56-63)(57-65)(58-68)(59-64)(60-66)(61-62)(61-63)(61-67)(62-65)(62-66)(64-66)(65-68)(67-69)(68-69)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| LNCaP | 6.4 | — | 10.1039/c7dt00938k | 2017 |
| HFF-1 | 6.6 | — | 10.1039/c7dt00938k | 2017 |
| MCF-7 | 6.9 | — | 10.1039/c7dt00938k | 2017 |
| HepG2 | 11 | — | 10.1039/c7dt00938k | 2017 |
| MIA PaCa-2 | 12 | — | 10.1039/c7dt00938k | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«Apoptotic cell death is supported for 1–3 because the formation of fragmented bands of the isolated genomic DNA of the metal complex-treated MCF-7 cells (DNA ladder; Fig. S33†) was observed. Involveme...»