Info
| ID | 1057 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"S": 1, "N": 3, "P": 2} |
| Abbreviation | 1 |
| SMILES | [S-]C1=NCCS1.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C41H40N3P2RuS2/(1-41)(2-43)(3-42)(4-74)(5-45)(6-46)(7-47)(8-44)(9-67)(10-54)(11-52)(12-74)(13-67)(14-51)(15-56)(16-57)(17-68)(18-68)(19-53)(20-58)(21-59)(22-62)(23-55)(24-60)(25-63)(26-75)(27-61)(28-75)(29-48)(30-69)(31-70)(32-49)(33-50)(34-80)(35-80)(36-71)(37-71)(38-64)(39-65)(40-66)(41-45)(41-76)(42-45)(42-46)(43-46)(43-76)(44-47)(44-77)(47-51)(48-50)(48-72)(49-50)(49-69)(51-52)(52-54)(53-57)(53-58)(54-77)(55-62)(55-63)(56-57)(56-78)(58-59)(59-78)(60-62)(60-79)(61-63)(61-79)(64-65)(64-66)(65-70)(66-73)(67-68)(67-74)(68-75)(69-82)(70-83)(71-80)(71-84)(72-73)(72-82)(73-83)(74-85)(75-86)(76-85)(77-85)(78-86)(79-86)(80-88)(81-84)(81-87)(81-88)(82-89)(83-89)(84-89)(85-89)(86-89)(88-89)
Measurements (16)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.2 | — | 10.1039/C9DT01905G | 2019 |
| A549 | 0.21 | — | 10.1039/C9DT01905G | 2019 |
| DU-145 | 0.3 | — | 10.1016/j.jinorgbio.2015.12.02... | 2016 |
| K-562 | 0.9 | — | 10.3389/fonc.2019.00562 | 2019 |
| HepG2 | 0.94 | — | 10.1039/C9DT01905G | 2019 |
| MCF-7 | 1.1 | — | 10.1016/j.jinorgbio.2015.12.02... | 2016 |
| HL60 | 1.1 | — | 10.3389/fonc.2019.00562 | 2019 |
| B16-F10 | 1.3 | — | 10.3389/fonc.2019.00562 | 2019 |
| DU-145 | 1.4 | — | 10.1039/C9DT01905G | 2019 |
| MCF-7 | 1.6 | — | 10.1039/C9DT01905G | 2019 |
| HepG2 | 1.9 | — | 10.3389/fonc.2019.00562 | 2019 |
| HSC-3 | 2.2 | — | 10.3389/fonc.2019.00562 | 2019 |
| HCT-116 | 2.7 | — | 10.3389/fonc.2019.00562 | 2019 |
| MRC-5 | 3.7 | — | 10.1039/C9DT01905G | 2019 |
| SCC-4 | 3.9 | — | 10.3389/fonc.2019.00562 | 2019 |
| MCF-7 | 7.3 | — | 10.3389/fonc.2019.00562 | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«coincubation with a pan-caspase inhibitor (Z-VAD(OMe)-FMK) reduced the levels of apoptosis that were induced by these compounds compared to those in the negative controls, indicating that cell death t...»