Info
| ID | 1054 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | RM175 |
| SMILES | NCCN.[Cl-].c1ccc(-c2ccccc2)cc1 |
TUCAN
C14ClN2Ru/(1-2)(1-3)(2-11)(3-4)(4-6)(5-7)(5-9)(6-11)(7-12)(8-9)(8-10)(10-12)(11-12)(13-14)(13-15)(14-16)
Measurements (14)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| KB | 2.6 | — | 10.1016/j.jinorgbio.2008.01.00... | 2008 |
| A549 | 3 | — | 10.1016/j.bcp.2005.10.053 | 2006 |
| H520 | 3.5 | — | 10.1016/j.bcp.2005.10.053 | 2006 |
| A2780 | 5 | — | 10.1038/sj.bjc.6600290 | 2002 |
| A2780cisR | 5 | — | 10.1038/sj.bjc.6600290 | 2002 |
| A2780 | 6 | — | 10.1021/jm010051m | 2001 |
| A549 | 6.2 | — | 10.1002/chem.201202657 | 2013 |
| MCF-7 | 6.6 | — | 10.1021/ic4002626 | 2013 |
| NB4 | 7.2 | — | 10.1039/c9sc03110c | 2019 |
| CH-1 | 9.2 | — | 10.1002/chem.201202657 | 2013 |
| MDA-MB-231 | 10 | — | 10.1016/j.jinorgbio.2008.01.00... | 2008 |
| SW480 | 12 | — | 10.1002/chem.201202657 | 2013 |
| A2780/ADR | 1.9e+02 | — | 10.1038/sj.bjc.6600290 | 2002 |
| DLD-1 | — | — | 10.1038/srep20596 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«To verify the cell apoptosis resulting from the DNA binding of Ru-1, the expression of apoptotic pathway proteins, including caspase-3, cleaved caspase-3, PARP-1 and cleaved PARP-1, was measured... Th...»