Info
| ID | 103 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 2} |
| Abbreviation | 6 |
| SMILES | COc1ccc(/C([O-])=N/N=C\c2c3ccccc3cc3ccccc23)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C33H31N2O2Ru/(1-32)(2-36)(3-32)(4-35)(5-32)(6-37)(7-33)(8-33)(9-33)(10-38)(11-34)(12-48)(13-41)(14-44)(15-43)(16-40)(17-46)(18-42)(19-39)(20-34)(21-50)(22-62)(23-62)(24-62)(25-49)(26-45)(27-34)(28-60)(29-51)(30-61)(31-47)(32-60)(33-60)(34-57)(35-36)(35-52)(36-57)(37-38)(37-52)(38-57)(39-48)(39-58)(40-43)(40-44)(41-55)(41-59)(42-44)(42-55)(43-53)(45-46)(45-47)(46-51)(47-59)(48-63)(49-50)(49-58)(50-63)(51-56)(52-60)(53-54)(53-55)(54-56)(54-61)(56-59)(58-64)(61-65)(62-68)(63-68)(64-66)(64-67)(65-66)(65-69)(66-69)(68-69)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 5 | — | 10.1039/c6qi00197a | 2016 |
| HepG2 | 10 | — | 10.1039/c6qi00197a | 2016 |
| HeLa | 14 | — | 10.1039/c6qi00197a | 2016 |
| NIH-3T3 | 2.4e+02 | — | 10.1039/c6qi00197a | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Furthermore, the results of AO–EB, Hoechst 33258 and flow cytometry analyses reveal that these complexes induce cell death only through apoptosis.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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