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Complex #922 — Ru(2) [RXC]

2D Structure

Structure
⬇ MOL V3000

Info

ID922
MetalRu
Oxidation state2
Charge1
Donor atoms{"O": 1, "N": 4}
AbbreviationRXC
SMILESCOc1cc([O-])c(C(C)=O)c(OC)c1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12

TUCAN

C34H27N4O4Ru/(1-48)(2-49)(3-29)(4-50)(5-32)(6-30)(7-35)(8-38)(9-56)(10-57)(11-57)(12-57)(13-56)(14-31)(15-34)(16-33)(17-36)(18-39)(19-56)(20-28)(21-28)(22-51)(23-37)(24-40)(25-41)(26-28)(27-42)(28-61)(29-30)(29-43)(30-48)(31-35)(31-49)(32-34)(32-43)(33-36)(33-50)(34-45)(35-45)(36-46)(37-40)(37-46)(38-58)(38-59)(39-41)(39-47)(40-47)(41-51)(42-58)(42-60)(43-52)(44-59)(44-60)(44-61)(45-53)(46-54)(47-55)(48-62)(49-63)(50-64)(51-65)(52-53)(52-62)(53-63)(54-55)(54-64)(55-65)(56-69)(57-68)(58-69)(59-68)(60-67)(61-66)(62-70)(63-70)(64-70)(65-70)(69-70)

Measurements (45)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
BJ0.76— 10.1038/s41419-023-06330-w 2023
OVCAR-31.5— 10.1038/s41419-023-06330-w 2023
HCT-1161.6— 10.1038/s41419-017-0104-6 2018
SCC-41.9— 10.1038/s41419-023-06330-w 2023
KG-1a2.3— 10.1038/s41419-023-06330-w 2023
MDA-MB-2312.4— 10.1038/s41419-023-06330-w 2023
B16-F102.6— 10.1038/s41419-023-06330-w 2023
THP-12.8— 10.1038/s41419-023-06330-w 2023
SCC-92.8— 10.1038/s41419-023-06330-w 2023
HL603.2— 10.1038/s41419-023-06330-w 2023
NB43.4— 10.1038/s41419-023-06330-w 2023
HT-293.4— 10.1038/s41419-017-0104-6 2018
SCC-93.4— 10.1038/s41419-017-0104-6 2018
A3753.5— 10.1038/s41419-023-06330-w 2023
K-5623.9— 10.1038/s41419-023-06330-w 2023
Jurkat4.1— 10.1038/s41419-023-06330-w 2023
DU-1454.2— 10.1038/s41419-023-06330-w 2023
PBMC4.6— 10.1038/s41419-017-0104-6 2018
HSC-34.8— 10.1038/s41419-023-06330-w 2023
PBMC4.9— 10.1038/s41419-023-06330-w 2023
SCC-45.3— 10.1038/s41419-017-0104-6 2018
AGP-015.3— 10.1038/s41419-017-0104-6 2018
CAL-275.4— 10.1038/s41419-023-06330-w 2023
K-5626.1— 10.1038/s41419-017-0104-6 2018
HaCaT6.1— 10.1038/s41419-017-0104-6 2018
HepG26.3— 10.1038/s41419-023-06330-w 2023
HCT-1166.5— 10.1038/s41419-023-06330-w 2023
SCC-256.5— 10.1038/s41419-017-0104-6 2018
HL606.6— 10.1038/s41419-017-0104-6 2018
SCC-156.8— 10.1038/s41419-017-0104-6 2018
A5497— 10.1038/s41419-023-06330-w 2023
U-87 MG7— 10.1038/s41419-023-06330-w 2023
HSC-37.7— 10.1038/s41419-017-0104-6 2018
4T19.1— 10.1038/s41419-023-06330-w 2023
MCF-79.6— 10.1038/s41419-023-06330-w 2023
SCC-2510— 10.1038/s41419-023-06330-w 2023
NCI-H129911— 10.1038/s41419-023-06330-w 2023
PANC-112— 10.1038/s41419-023-06330-w 2023
B16-F1012— 10.1038/s41419-017-0104-6 2018
HepG214— 10.1038/s41419-017-0104-6 2018
ACP-0218— 10.1038/s41419-017-0104-6 2018
MRC-521— 10.1038/s41419-017-0104-6 2018
MRC-521— 10.1038/s41419-023-06330-w 2023
MCF-722— 10.1038/s41419-017-0104-6 2018
ACP-0326— 10.1038/s41419-017-0104-6 2018

🧬 Cell Death Types (2)

Apoptosis high
«RXC causes apoptotic cell death in HCT116 CRC cells ... RXC caused DNA fragmentation ... increased levels of PARP cleavage (Asp214) ... mitochondrial depolarization»
Autophagy high
«RXC induces autophagy in HCT116 CRC cells ... RXC increased LC3B expression while decreasing p62/SQSTM1 expression, indicating that RXC induces autophagy»