home← all complexes D-MPNN

Complex #73 — Ru(2) [RuCl2(DIP)2]

2D Structure

Structure
⬇ MOL V3000

Info

ID73
MetalRu
Oxidation state2
Charge0
Donor atoms{"N": 4}
AbbreviationRuCl2(DIP)2
SMILES[Cl-].[Cl-].c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1

TUCAN

C48H32N4Ru/(1-35)(2-36)(3-33)(4-41)(5-37)(6-43)(7-34)(8-38)(9-48)(10-40)(11-49)(12-44)(13-39)(14-46)(15-45)(16-73)(17-53)(18-74)(19-50)(20-75)(21-42)(22-52)(23-59)(24-55)(25-51)(26-54)(27-76)(28-47)(29-56)(30-57)(31-58)(32-60)(33-35)(33-36)(34-35)(34-41)(36-64)(37-62)(37-73)(38-39)(38-43)(39-44)(40-46)(40-61)(41-64)(42-45)(42-52)(43-66)(44-48)(45-49)(46-63)(47-68)(47-74)(48-66)(49-67)(50-51)(50-65)(51-71)(52-53)(53-67)(54-55)(54-59)(55-72)(56-59)(56-60)(57-69)(57-75)(58-70)(58-76)(60-72)(61-62)(61-77)(62-64)(63-68)(63-78)(65-69)(65-79)(66-68)(67-69)(70-71)(70-72)(71-80)(73-81)(74-82)(75-83)(76-84)(77-78)(77-81)(78-82)(79-80)(79-83)(80-84)(81-85)(82-85)(83-85)(84-85)

Measurements (40)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
RPE-13.1— 10.1002/chem.201904877 2020
RPE-13.1— 10.1021/acs.inorgchem.9b03562 2020
RPE-13.1— 10.1021/acs.jmedchem.0c00431 2020
HepG24.3— 10.1016/j.ejmech.2022.114312 2022
A27804.7— 10.1002/chem.201904877 2020
A27804.7— 10.1021/acs.jmedchem.0c00431 2020
MRC-55.5— 10.1021/acs.jmedchem.0c00431 2020
A2780cisR6.4— 10.1002/chem.201904877 2020
A2780cisR6.4— 10.1021/acs.jmedchem.0c00431 2020
CT-26 LUC6.7— 10.1002/chem.201904877 2020
CT-26 LUC6.7— 10.1021/acs.jmedchem.0c00431 2020
HL-77027.4— 10.1016/j.ejmech.2022.114312 2022
MGC-8038.1— 10.1016/j.ejmech.2022.114312 2022
T248.2— 10.1016/j.ejmech.2022.114312 2022
CT-269.2— 10.1002/chem.201904877 2020
CT-269.2— 10.1021/acs.jmedchem.0c00431 2020
HeLa10— 10.1016/j.ejmech.2022.114312 2022
HEK29312— 10.1021/acs.inorgchem.9b03562 2020
SK-OV-314— 10.1016/j.ejmech.2022.114312 2022
HeLa15— 10.1002/chem.201904877 2020
HeLa15— 10.1021/acs.jmedchem.0c00431 2020
U-87 MG26— 10.1021/acs.inorgchem.9b03562 2020
MDA-MB-435S28— 10.1021/acs.inorgchem.9b03562 2020
BEL-740236— 10.1016/j.ejmech.2022.114312 2022
A2780/ADR78— 10.1002/chem.201904877 2020
A2780/ADR78— 10.1021/acs.jmedchem.0c00431 2020
HepG21.1e+02— 10.1021/jm1009296 2010
HepG21.1e+02— 10.1155/2020/8890950 2020
HepG21.1e+02— 10.1039/c1dt10084j 2011
HeLa1.2e+02— 10.1155/2020/8890950 2020
HeLa1.2e+02— 10.1039/c1dt10084j 2011
HeLa1.2e+02— 10.1021/jm1009296 2010
MCF-71.3e+02— 10.1155/2020/8890950 2020
A5491.4e+02— 10.1155/2020/8890950 2020
MCF-71.4e+02— 10.1039/c1dt10084j 2011
MCF-71.4e+02— 10.1021/jm1009296 2010
MCF-10A1.6e+02— 10.1039/c1dt10084j 2011
MCF-10A1.7e+02— 10.1021/jm1009296 2010
MCF-7—— 10.1021/acs.inorgchem.9b03562 2020
FaDu—— 10.1021/acs.inorgchem.9b03562 2020

🧬 Cell Death Types (1)

Apoptosis high
«Further studies revealed that these complexes could induce apoptosis in A549 cells, including activating caspase family proteins and poly (ADP-ribose) polymerase (PARP), reducing Bcl-2/Bax and Bcl-xl/...»