Info
| ID | 6162 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"O": 3, "N": 4} |
| Abbreviation | Re1 |
| SMILES | [C-]#[O+].[C-]#[O+].[C-]#[O+].c1cc(CCc2ccncc2)ccn1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C27H20N4O3Re/(1-22)(2-37)(3-30)(4-23)(5-25)(6-38)(7-26)(8-39)(9-41)(10-27)(11-40)(12-29)(13-31)(14-21)(15-31)(16-28)(17-42)(18-32)(19-32)(20-24)(21-24)(21-33)(22-23)(22-37)(23-33)(24-36)(25-34)(25-38)(26-34)(26-39)(27-35)(27-40)(28-35)(28-42)(29-30)(29-36)(30-41)(31-32)(31-34)(32-35)(33-43)(36-44)(37-48)(38-49)(39-49)(40-51)(41-50)(42-51)(43-44)(43-48)(44-50)(45-52)(46-53)(47-54)(48-55)(49-55)(50-55)(51-55)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 40 | — | 10.1002/chem.201505160 | 2016 |
| HeLa | 45 | — | 10.1002/chem.201505160 | 2016 |
| A549 | — | — | 10.1002/chem.201505160 | 2016 |
| A549cisR | — | — | 10.1002/chem.201505160 | 2016 |
| LO2 | — | — | 10.1002/chem.201505160 | 2016 |
🧬 Cell Death Types (2)
Apoptosis
high
«Re3 with a lower lipophilicity localizes to lysosomes and induces caspase-independent apoptosis»
Paraptosis
high
«Re4 with higher lipophilicity specially accumulates in mitochondria and induces caspase-independent paraptosis in cancer cells»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
Loading source metadata…
The generated SVG will appear here. The legacy ligand image above stays visible for side-by-side review.