Info
| ID | 4667 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 2 |
| SMILES | c1c[nH]c(-c2ncc[nH]2)n1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C30H22N8Ru/(1-39)(2-25)(3-29)(4-40)(5-42)(6-23)(7-26)(8-41)(9-30)(10-27)(11-24)(12-43)(13-46)(14-44)(15-32)(16-28)(17-33)(18-34)(19-31)(20-45)(21-53)(22-54)(23-24)(23-35)(24-36)(25-26)(25-39)(26-35)(27-29)(27-36)(28-30)(28-37)(29-40)(30-41)(31-34)(31-38)(32-33)(32-37)(33-38)(34-44)(35-47)(36-48)(37-49)(38-50)(39-55)(40-56)(41-57)(42-43)(42-59)(43-53)(44-58)(45-46)(45-54)(46-60)(47-48)(47-55)(48-56)(49-50)(49-57)(50-58)(51-52)(51-53)(51-59)(52-54)(52-60)(55-61)(56-61)(57-61)(58-61)(59-61)(60-61)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 14 | — | 10.1039/c3nj00542a | 2013 |
| A549 | 19 | — | 10.1039/c3nj00542a | 2013 |
| HepG2 | 30 | — | 10.1039/c3nj00542a | 2013 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis and evaluation of mitochondrial membrane potential demonstrated that complex 2 inhibited the growth of HeLa cells through induction of apoptotic cell death.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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