Info
| ID | 3854 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 3, "P": 2} |
| Abbreviation | 2 |
| SMILES | COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OC.c1ccc(-c2ccccn2)nc1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C55H55N3O5P2Ru/(1-88)(2-56)(3-88)(4-57)(5-67)(6-58)(7-69)(8-105)(9-59)(10-89)(11-60)(12-105)(13-106)(14-68)(15-89)(16-98)(17-97)(18-97)(19-87)(20-90)(21-92)(22-106)(23-73)(24-64)(25-72)(26-76)(27-78)(28-98)(29-97)(30-63)(31-74)(32-75)(33-80)(34-77)(35-81)(36-82)(37-61)(38-79)(39-66)(40-93)(41-83)(42-62)(43-90)(44-65)(45-98)(46-99)(47-71)(48-85)(49-70)(50-84)(51-99)(52-99)(53-94)(54-86)(55-94)(56-57)(56-58)(57-107)(58-67)(59-67)(59-107)(60-69)(60-72)(61-63)(61-95)(62-66)(62-96)(63-64)(64-92)(65-66)(65-93)(68-69)(68-108)(70-86)(70-91)(71-91)(71-101)(72-73)(73-108)(74-76)(74-78)(75-78)(75-81)(76-109)(77-80)(77-82)(79-80)(79-83)(81-109)(82-110)(83-110)(84-91)(84-102)(85-87)(85-103)(86-104)(87-90)(88-89)(88-105)(89-106)(90-94)(92-112)(93-113)(94-111)(95-96)(95-112)(96-113)(97-116)(98-117)(99-118)(100-101)(100-102)(100-116)(101-117)(102-118)(103-111)(103-114)(104-111)(104-115)(105-119)(106-120)(107-119)(108-119)(109-120)(110-120)(112-121)(113-121)(116-121)(117-121)(118-121)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HSC-3 | 1.3 | — | 10.18632/oncotarget.22248 | 2017 |
| HepG2 | 1.9 | — | 10.18632/oncotarget.22248 | 2017 |
| PBMC | 3.2 | — | 10.18632/oncotarget.22248 | 2017 |
| B16-F10 | 4.1 | — | 10.18632/oncotarget.22248 | 2017 |
| HL60 | 4.5 | — | 10.18632/oncotarget.22248 | 2017 |
| SCC-4 | 5.4 | — | 10.18632/oncotarget.22248 | 2017 |
| HCT-116 | 5.5 | — | 10.18632/oncotarget.22248 | 2017 |
| K-562 | 5.8 | — | 10.18632/oncotarget.22248 | 2017 |
| MRC-5 | 6.3 | — | 10.18632/oncotarget.22248 | 2017 |
| SCC-9 | 6.8 | — | 10.18632/oncotarget.22248 | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies uncovered that the complexes reduced the cell growth and caused phosphatidylserine externalization, internucleosomal DNA fragmentation, caspase-3 activation and loss of the mitocho...»
Source-assisted 2D generator
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