Info
| ID | 357 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "O": 1, "P": 1} |
| Abbreviation | Ru7 |
| SMILES | Cc1ccnc(-c2cc(C)ccn2)c1.OC[c-]1cccc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H34N2OPRu/(1-67)(2-38)(3-45)(4-37)(5-50)(6-43)(7-44)(8-67)(9-39)(10-52)(11-35)(12-35)(13-58)(14-35)(15-49)(16-51)(17-54)(18-42)(19-63)(20-41)(21-40)(22-53)(23-55)(24-56)(25-47)(26-57)(27-46)(28-36)(29-36)(30-59)(31-64)(32-48)(33-36)(34-73)(35-60)(36-61)(37-38)(37-68)(38-43)(39-45)(39-68)(40-42)(40-47)(41-60)(41-63)(42-62)(43-45)(44-50)(44-52)(46-47)(46-62)(48-61)(48-64)(49-50)(49-69)(51-52)(51-69)(53-55)(53-56)(54-55)(54-70)(56-57)(57-70)(58-60)(58-65)(59-61)(59-66)(62-67)(63-71)(64-72)(65-66)(65-71)(66-72)(67-73)(68-74)(69-74)(70-74)(71-75)(72-75)(73-75)(74-75)
Measurements (18)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.05 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| MDA-MB-231 | 0.31 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| RKO | 0.61 | — | 10.3390/pharmaceutics14061293 | 2022 |
| EA.hy926 | 2.3 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| V79 | 2.4 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| EA.hy926 | 3.5 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| SW480 | 3.9 | — | 10.3390/pharmaceutics14061293 | 2022 |
| NCM460 | 7.4 | — | 10.3390/pharmaceutics14061293 | 2022 |
| HdFa | 14 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| EA.hy926 | 14 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| H9c2 | 16 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| H9c2 | 28 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HSAEC | 30 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HdFa | 38 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HSAEC | 40 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| H9c2 | 50 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HdFa | 80 | — | 10.1016/j.phrs.2024.107353 | 2024 |
| HSAEC | — | — | 10.1016/j.phrs.2024.107353 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Based on the results obtained with this assay, we conclude that these compounds induced cell death by apoptosis.»
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