Info
| ID | 2637 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 4 |
| SMILES | COc1cc(/N=C/c2ccccn2)cc(OC)c1OC.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C25H30N2O3Ru/(1-34)(2-38)(3-31)(4-33)(5-31)(6-33)(7-33)(8-50)(9-31)(10-32)(11-32)(12-35)(13-32)(14-36)(15-45)(16-37)(17-40)(18-47)(19-51)(20-39)(21-51)(22-51)(23-41)(24-46)(25-42)(26-52)(27-50)(28-52)(29-52)(30-50)(31-45)(32-45)(33-44)(34-35)(34-43)(35-44)(36-38)(36-44)(37-40)(37-42)(38-43)(39-49)(39-54)(40-48)(41-49)(41-55)(42-46)(43-45)(46-57)(47-48)(47-56)(48-57)(49-56)(50-60)(51-58)(52-59)(53-54)(53-55)(53-60)(54-58)(55-59)(56-61)(57-61)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MIA PaCa-2 | — | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
| HepG2 | — | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
| MDA-MB-231 | — | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
| HEK293 | — | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
| HFF-1 | — | — | 10.1021/acs.inorgchem.0c03820 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Cellular studies show that all of the N,O-coordinated complexes (1–3) initiate disruption of the microtubule network in MDA-MB-231 cells in a dose-dependent manner within 6 h of incubation and finally...»