Info
| ID | 1564 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 3 |
| SMILES | CN(C)c1ccc(/N=N/c2ccccn2)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C23H28N4Ru/(1-45)(2-29)(3-33)(4-29)(5-29)(6-37)(7-32)(8-31)(9-30)(10-31)(11-31)(12-38)(13-42)(14-35)(15-34)(16-46)(17-46)(18-46)(19-47)(20-41)(21-47)(22-48)(23-30)(24-30)(25-36)(26-40)(27-39)(28-47)(29-45)(30-44)(31-45)(32-33)(32-44)(33-43)(34-35)(34-50)(35-49)(36-37)(36-44)(37-43)(38-41)(38-42)(39-40)(39-49)(40-50)(41-48)(42-51)(43-45)(46-53)(47-53)(48-52)(49-55)(50-53)(51-52)(51-54)(54-55)(54-56)(55-56)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 12 | — | 10.1021/jm3017442 | 2013 |
| A2780 | 13 | — | 10.1021/jm3017442 | 2013 |
| A549 | 15 | — | 10.1021/jm3017442 | 2013 |
| HCT-116 | 17 | — | 10.1021/jm3017442 | 2013 |
| A2780 | — | — | 10.1021/ic061460h | 2006 |
| A549 | — | — | 10.1021/ic061460h | 2006 |
🧬 Cell Death Types (1)
Apoptosis
high
«All complexes activate caspase 3. Remarkably, the level of activation of caspase 3 by the chlorido complexes 1, 3, and 5 is 2-fold higher than by the iodido complexes 2, 4, and 6 (Supporting Informati...»