Info
| ID | 1228 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 3 |
| SMILES | CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.c1ccc2c(c1)cc(-c1nc3c4cccnc4c4ncccc4c3[nH]1)c1ccccc12 |
TUCAN
C63H64N8Ru/(1-79)(2-113)(3-89)(4-82)(5-88)(6-83)(7-65)(8-65)(9-65)(10-87)(11-66)(12-66)(13-66)(14-67)(15-90)(16-115)(17-91)(18-67)(19-67)(20-68)(21-68)(22-68)(23-69)(24-69)(25-69)(26-70)(27-70)(28-70)(29-71)(30-81)(31-86)(32-71)(33-71)(34-72)(35-80)(36-72)(37-72)(38-73)(39-73)(40-116)(41-114)(42-77)(43-84)(44-92)(45-78)(46-96)(47-118)(48-94)(49-73)(50-95)(51-85)(52-74)(53-74)(54-74)(55-75)(56-75)(57-75)(58-93)(59-76)(60-97)(61-76)(62-76)(63-117)(64-129)(65-109)(66-109)(67-109)(68-110)(69-110)(70-110)(71-111)(72-111)(73-111)(74-112)(75-112)(76-112)(77-78)(77-106)(78-82)(79-102)(79-121)(80-85)(80-100)(81-86)(81-101)(82-87)(83-95)(83-98)(84-96)(84-114)(85-118)(86-95)(87-105)(88-98)(88-99)(89-102)(89-113)(90-103)(90-122)(91-103)(91-115)(92-104)(92-116)(93-108)(93-117)(94-104)(94-123)(96-107)(97-108)(97-124)(98-101)(99-105)(99-127)(100-119)(100-126)(101-106)(102-109)(103-110)(104-111)(105-106)(107-120)(107-125)(108-112)(113-131)(114-130)(115-132)(116-133)(117-134)(118-128)(119-125)(119-129)(120-126)(120-130)(121-122)(121-131)(122-132)(123-124)(123-133)(124-134)(125-135)(126-128)(127-129)(127-135)(130-136)(131-136)(132-136)(133-136)(134-136)(135-136)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NIH-3T3 | 9 | — | 10.1039/c7ra05103d | 2017 |
| SGC-7901 | 18 | — | 10.1039/c7ra05103d | 2017 |
| SiHa | 38 | — | 10.1039/c7ra05103d | 2017 |
| HepG2 | — | — | 10.1039/c7ra05103d | 2017 |
| HeLa | — | — | 10.1039/c7ra05103d | 2017 |
🧬 Cell Death Types (2)
Apoptosis
high
«The results demonstrate that the complexes induce apoptosis in SGC-7901 cells through a ROS-mediated mitochondrial dysfunction pathway»
Autophagy
high
«which also indicates that complex 3 can induce autophagy»