Info
| ID | 1097 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 5 |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.Cc1ccc2ccc3ccc(C)nc3c2n1.Fc1cc2ccccc2cc1Oc1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C56H39FN8ORu/(1-40)(2-52)(3-56)(4-40)(5-78)(6-63)(7-53)(8-77)(9-66)(10-40)(11-48)(12-50)(13-49)(14-51)(15-58)(16-57)(17-62)(18-64)(19-67)(20-41)(21-41)(22-65)(23-55)(24-61)(25-41)(26-42)(27-42)(28-45)(29-44)(30-46)(31-47)(32-54)(33-60)(34-42)(35-59)(36-43)(37-43)(38-43)(39-68)(40-82)(41-85)(42-86)(43-92)(44-47)(44-73)(45-46)(45-61)(46-53)(47-77)(48-50)(48-82)(49-51)(49-85)(50-69)(51-71)(52-56)(52-69)(53-70)(54-59)(54-83)(55-84)(55-93)(56-71)(57-58)(57-75)(58-86)(59-93)(60-72)(60-94)(61-72)(62-64)(62-74)(63-70)(63-95)(64-78)(65-68)(65-76)(66-67)(66-75)(67-76)(68-92)(69-79)(70-72)(71-81)(73-87)(73-89)(74-80)(74-88)(75-90)(76-91)(77-96)(78-101)(79-81)(79-99)(80-87)(80-98)(81-100)(82-99)(83-84)(83-98)(84-97)(85-100)(86-102)(87-97)(88-89)(88-101)(89-96)(90-91)(90-102)(91-103)(92-103)(93-104)(94-95)(94-104)(95-105)(98-106)(99-106)(100-106)(101-106)(102-106)(103-106)(104-106)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 2.5 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HOS | 2.6 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HepG2 | 3.7 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 6.1 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 6.1 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HeLa | 10 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| LO2 | 13 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
🧬 Cell Death Types (2)
Apoptosis
high
«The results obtained show that the complexes induce apoptosis in BEL-7402 cells through a ROS-mediated mitochondrial dysfunction pathway.»
Autophagy
high
«the complexes can induce autophagy and restrain the cell invasion... the expression of LC3-II and Beclin-1 was increased.»