Info
| ID | 1096 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | 4 |
| SMILES | Cc1ccnc(-c2cc(C)ccn2)c1.Cc1ccnc(-c2cc(C)ccn2)c1.Fc1cc2ccccc2cc1Oc1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C52H39FN8ORu/(1-40)(2-76)(3-40)(4-61)(5-40)(6-48)(7-41)(8-59)(9-49)(10-46)(11-41)(12-53)(13-41)(14-58)(15-47)(16-42)(17-73)(18-50)(19-63)(20-45)(21-62)(22-54)(23-60)(24-52)(25-42)(26-74)(27-77)(28-44)(29-57)(30-55)(31-42)(32-51)(33-43)(34-43)(35-75)(36-56)(37-64)(38-78)(39-43)(40-65)(41-66)(42-68)(43-72)(44-70)(44-91)(45-47)(45-54)(46-51)(46-79)(47-69)(48-65)(48-73)(49-65)(49-82)(50-66)(50-74)(51-89)(52-54)(52-70)(53-66)(53-85)(55-68)(55-75)(56-72)(56-78)(57-69)(57-90)(58-80)(58-89)(59-61)(59-71)(60-62)(60-77)(61-76)(62-67)(63-68)(63-87)(64-72)(64-88)(67-81)(67-84)(69-70)(71-83)(71-86)(73-94)(74-96)(75-98)(76-95)(77-92)(78-99)(79-80)(79-97)(80-93)(81-83)(81-92)(82-85)(82-94)(83-95)(84-86)(84-93)(85-96)(86-97)(87-88)(87-98)(88-99)(89-100)(90-91)(90-100)(91-101)(94-102)(95-102)(96-102)(97-102)(98-102)(99-102)(100-102)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 9.8 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 12 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| BEL-7402 | 12 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HOS | 21 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| A549 | 26 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| LO2 | 53 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
| HeLa | 56 | — | 10.1016/j.jinorgbio.2017.04.02... | 2017 |
🧬 Cell Death Types (2)
Apoptosis
high
«The results obtained show that the complexes induce apoptosis in BEL-7402 cells through a ROS-mediated mitochondrial dysfunction pathway.»
Autophagy
high
«the complexes can induce autophagy and restrain the cell invasion... the expression of LC3-II and Beclin-1 was increased.»