Info
| ID | 109 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 3} |
| Abbreviation | 6 |
| SMILES | COc1ccc(/C([O-])=N/N=C\C2=CNC3C=CC=CC23)cc1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C27H30N3O2Ru/(1-31)(2-34)(3-31)(4-33)(5-31)(6-36)(7-32)(8-32)(9-42)(10-35)(11-32)(12-50)(13-39)(14-40)(15-33)(16-53)(17-52)(18-37)(19-55)(20-55)(21-43)(22-55)(23-54)(24-44)(25-33)(26-38)(27-41)(28-45)(29-51)(30-58)(31-50)(32-50)(33-47)(34-36)(34-47)(35-42)(35-47)(36-46)(37-43)(37-48)(38-40)(38-41)(39-40)(39-51)(41-54)(42-46)(43-56)(44-45)(44-48)(45-56)(46-50)(48-57)(49-51)(49-52)(49-53)(51-54)(52-59)(53-58)(54-58)(55-62)(56-62)(57-60)(57-61)(59-60)(59-63)(60-63)(62-63)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 4.1 | — | 10.1039/c6nj01936f | 2016 |
| HepG2 | 9.1 | — | 10.1039/c6nj01936f | 2016 |
| HeLa | 11 | — | 10.1039/c6nj01936f | 2016 |
| NIH-3T3 | 2.4e+02 | — | 10.1039/c6nj01936f | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«the results of Western blot analyses suggest that complexes 3 and 6 accumulate preferentially in the mitochondria of MDA-MB-231 cells and induce apoptosis via mitochondrial pathways by up-regulating p...»