Info
| ID | 108 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 3} |
| Abbreviation | 5 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[O-]/C(=N\N=C/C1=CNC2C=CC=CC12)c1ccc(Cl)cc1 |
TUCAN
C26H27ClN3ORu/(1-50)(2-28)(3-36)(4-29)(5-35)(6-28)(7-33)(8-32)(9-40)(10-38)(11-31)(12-51)(13-48)(14-34)(15-49)(16-41)(17-39)(18-42)(19-29)(20-28)(21-29)(22-37)(23-30)(24-30)(25-30)(26-47)(27-54)(28-44)(29-47)(30-47)(31-34)(31-51)(32-34)(32-41)(33-38)(33-53)(35-36)(35-44)(36-45)(37-42)(37-45)(38-46)(39-40)(39-46)(40-53)(41-48)(42-44)(43-48)(43-49)(43-50)(45-47)(46-52)(48-51)(49-55)(50-54)(51-54)(52-56)(52-57)(53-58)(55-56)(55-59)(56-59)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 13 | — | 10.1039/c6nj01936f | 2016 |
| HepG2 | 13 | — | 10.1039/c6nj01936f | 2016 |
| HeLa | 18 | — | 10.1039/c6nj01936f | 2016 |
| NIH-3T3 | 2.2e+02 | — | 10.1039/c6nj01936f | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«the results of Western blot analyses suggest that complexes 3 and 6 accumulate preferentially in the mitochondria of MDA-MB-231 cells and induce apoptosis via mitochondrial pathways by up-regulating p...»