Info
| ID | 107 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 3} |
| Abbreviation | 4 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[O-]/C(=N\N=C/C1=CNC2C=CC=CC12)c1ccccc1 |
TUCAN
C26H28N3ORu/(1-51)(2-52)(3-42)(4-50)(5-30)(6-35)(7-30)(8-36)(9-32)(10-37)(11-40)(12-41)(13-33)(14-38)(15-43)(16-49)(17-39)(18-53)(19-30)(20-34)(21-29)(22-31)(23-44)(24-31)(25-29)(26-29)(27-31)(28-55)(29-47)(30-50)(31-50)(32-40)(32-46)(33-38)(33-49)(34-35)(34-47)(35-48)(36-44)(36-48)(37-43)(37-46)(38-39)(39-42)(40-41)(41-43)(42-53)(44-47)(45-49)(45-51)(45-52)(46-54)(48-50)(49-53)(51-56)(52-55)(53-55)(54-57)(54-58)(56-57)(56-59)(57-59)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 11 | — | 10.1039/c6nj01936f | 2016 |
| HepG2 | 12 | — | 10.1039/c6nj01936f | 2016 |
| HeLa | 14 | — | 10.1039/c6nj01936f | 2016 |
| NIH-3T3 | 2.3e+02 | — | 10.1039/c6nj01936f | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«the results of Western blot analyses suggest that complexes 3 and 6 accumulate preferentially in the mitochondria of MDA-MB-231 cells and induce apoptosis via mitochondrial pathways by up-regulating p...»