Info
| ID | 106 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 3} |
| Abbreviation | 3 |
| SMILES | COc1ccc(/C([O-])=N/N=C\C2=CNC3C=CC=CC23)cc1.[Cl-].c1ccccc1 |
TUCAN
C23H22N3O2Ru/(1-23)(2-39)(3-32)(4-33)(5-24)(6-25)(7-26)(8-27)(9-29)(10-28)(11-34)(12-41)(13-31)(14-42)(15-30)(16-40)(17-35)(18-43)(19-43)(20-43)(21-36)(22-46)(23-24)(23-25)(24-26)(25-27)(26-28)(27-28)(29-33)(29-38)(30-34)(30-39)(31-32)(31-34)(32-42)(33-44)(35-36)(35-38)(36-44)(37-39)(37-40)(37-41)(38-45)(39-42)(40-47)(41-46)(42-46)(43-50)(44-50)(45-48)(45-49)(47-48)(47-51)(48-51)(50-51)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 13 | — | 10.1039/c6nj01936f | 2016 |
| MDA-MB-231 | 15 | — | 10.1039/c6nj01936f | 2016 |
| HeLa | 19 | — | 10.1039/c6nj01936f | 2016 |
| NIH-3T3 | 2.4e+02 | — | 10.1039/c6nj01936f | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«the results of Western blot analyses suggest that complexes 3 and 6 accumulate preferentially in the mitochondria of MDA-MB-231 cells and induce apoptosis via mitochondrial pathways by up-regulating p...»
Source-assisted 2D generator
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