Info
| ID | 105 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 3} |
| Abbreviation | 2 |
| SMILES | [Cl-].[O-]/C(=N\N=C/C1=CNC2C=CC=CC12)c1ccc(Cl)cc1.c1ccccc1 |
TUCAN
C22H19ClN3ORu/(1-20)(2-21)(3-22)(4-27)(5-23)(6-33)(7-29)(8-30)(9-36)(10-31)(11-26)(12-24)(13-25)(14-32)(15-28)(16-39)(17-38)(18-37)(19-42)(20-21)(20-22)(21-23)(22-24)(23-25)(24-25)(26-27)(26-41)(27-34)(28-29)(28-31)(29-30)(30-39)(31-36)(32-33)(32-41)(33-34)(34-40)(35-36)(35-37)(35-38)(36-39)(37-42)(38-44)(39-42)(40-43)(40-45)(41-46)(43-44)(43-47)(44-47)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 17 | — | 10.1039/c6nj01936f | 2016 |
| MDA-MB-231 | 20 | — | 10.1039/c6nj01936f | 2016 |
| HeLa | 26 | — | 10.1039/c6nj01936f | 2016 |
| NIH-3T3 | 2.2e+02 | — | 10.1039/c6nj01936f | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«the results of Western blot analyses suggest that complexes 3 and 6 accumulate preferentially in the mitochondria of MDA-MB-231 cells and induce apoptosis via mitochondrial pathways by up-regulating p...»