Info
| ID | 104 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 3} |
| Abbreviation | 1 |
| SMILES | [Cl-].[O-]/C(=N\N=C/C1=CNC2C=CC=CC12)c1ccccc1.c1ccccc1 |
TUCAN
C22H20N3ORu/(1-21)(2-22)(3-23)(4-24)(5-25)(6-26)(7-28)(8-29)(9-33)(10-30)(11-38)(12-35)(13-34)(14-27)(15-31)(16-32)(17-40)(18-39)(19-41)(20-43)(21-22)(21-23)(22-24)(23-25)(24-26)(25-26)(27-28)(27-30)(28-29)(29-36)(30-33)(31-32)(31-35)(32-41)(33-36)(34-35)(34-38)(36-42)(37-38)(37-39)(37-40)(38-41)(39-43)(40-45)(41-43)(42-44)(42-46)(44-45)(44-47)(45-47)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 14 | — | 10.1039/c6nj01936f | 2016 |
| MDA-MB-231 | 18 | — | 10.1039/c6nj01936f | 2016 |
| HeLa | 21 | — | 10.1039/c6nj01936f | 2016 |
| NIH-3T3 | 2.2e+02 | — | 10.1039/c6nj01936f | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«the results of Western blot analyses suggest that complexes 3 and 6 accumulate preferentially in the mitochondria of MDA-MB-231 cells and induce apoptosis via mitochondrial pathways by up-regulating p...»